Synergistic control of cell adhesion by integrins and syndecans

By M. Morgan, M. Humphries, M. Bass. Nature reviews. Molecular cell biology, 2007

598 citations recorded by the source corpus.

The ability of cells to adhere to each other and to their surrounding extracellular matrices is essential for a multicellular existence. Adhesion provides physical support for cells, regulates cell positioning and enables microenvironmental sensing. The integrins and the syndecans are two adhesion receptor families that mediate adhesion, but their relative and functional contributions to cell–extracellular matrix interactions remain obscure. Recent advances have highlighted connections between the signalling networks that are controlled by these families of receptors. Here we survey the evidence that synergistic signalling is involved in controlling adhesive function and the regulation of cell behaviour in response to the external environment.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/fef3bf4de2b736a41949556a725a4addea8797b9

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Citations in the corpus

Heparan sulfate proteoglycans. (2011, background): “When fibroblasts attach and spread in response to fibronectin fragments containing the RGD site, the formation of focal adhesions and stress fibers can often take place only if the heparin-binding domain of the fibronectin is also present (Saoncella et al. 1999; Woods et al. 2000; Morgan et al. 2007”
Syndecan–syntenin–ALIX regulates the biogenesis of exosomes (2012, background): “Note that truncated forms of Alix containing the V domain interact with the two parts of the N-Ter domain of syntenin that contain LYPXL motifs, (1-30) and (31-60), and that mutation of the three LYPXL motifs (YP to AA) abolishes the interaction.”
Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15 (2015, background): “The dynamics of syndecan4 on the cell surface are thus important, since either excess or absence of syndecan-4 impairs cell adhesion and migration.(18) Proteolytic shedding of the ectodomains of syndecans involves cleavage in the juxtamembrane region by a variety of MMPs.”
Extracellular matrix structure. (2016, background): “binding to the HepII domain enhances integrin-mediated cell spreading and intracellular signaling, suggesting that syndecans operate as co-receptors with integrins in cell–FN binding [190, 191].”
Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, background): “These include integrin associations with one or another RTK, with specific tetraspanins, syndecans, uPAR, CD44, and direct integrin recruitment of signaling components (Cantor et al., 2008; Danen and Yamada, 2001; Hemler, 2003; Kugler et al., 2003; Morgan et al., 2007).”
An Introduction to Proteoglycans and Their Localization (2012, background): “…of proteoglycans is the syndecans, which are transmembrane receptors capable of signaling independently or in combination with other receptors, such as fibroblast growth factor receptors or the cell adhesion receptors, integrins (Couchman, 2003; 2010; Morgan et al. 2007; Murakami and Simons 2008).”
Integrin signalling at a glance (2009, methodology): “We refer readers to several reviews (Alam et al., 2007; Morgan et al., 2007; Berditchevski, 2001) for a detailed discussion of these interactions.”
Virus Entry by Endocytosis (2013, unknown): “They regulate a wide variety of cellular processes such as cell migration, growth, phagocytosis, inflammation, wound healing, and neoplasia, and they also participate in adhesive events including haemostasis and thrombosis [44].”