Structural basis of integrin activation by talin.
By K. Wegener, A. Partridge, Jaewon Han, A. Pickford, R. Liddington, M. Ginsberg, Iain D. Campbell. Cell, 2007
709 citations recorded by the source corpus.
Subfields: Cell Biology, Immunology and Allergy, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/ffab6cb14e2e1ac7905ef496d4622779fd8167a2
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Citations in the corpus
- The final steps of integrin activation: the end game (2010, background): “More recent analysis of talin 1 structure has identified talin 1 and integrin mutants that have little effect on the binding of talin 1 to the β-integrin tail, or on talin 1 recruitment to integrin in cells, but do block the ability of talin 1 to induce activatio”
- Getting to the site of inflammation: the leukocyte adhesion cascade updated (2007, background): “Binding of talin-1 to the β 3 -integrin cytoplasmic domain induces or stabilizes the high-affinity conformation of the extracellular domain”
- Kindlin-3 is essential for integrin activation and platelet aggregation (2008, background): “The phosphotyrosine-binding (PTB) subdomain in the F3 domain sequentially binds to two distinct regions in the β cytoplasmic tails and is sufficient for integrin activation in vitro”
- Integrin Structure and Function (2010, background): “This is thought to be because the talin F3 subdomain binds to an additional, more proximal site on b integrin tails, which induces displacement of a and b integrin tails ( Wegener et al. 2007 ).”
- The integrins (2007, neutral): “The structural basis for talin’s unique ability to activate integrins through PTBs has been defined [9].”
- Integrins and extracellular matrix in mechanotransduction. (2010, background): “This is thought to occur through the disruption of inhibitory interactions between α and β subunit cytoplasmic tails.(32) Talin also binds to actin and to cytoskeletal and signaling proteins.”
- Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “The transcript abundance was normalized against peanut Ubiquitin (Luo et al. , 2005) transcript levels.”
- Genetic and cell biological analysis of integrin outside-in signaling. (2009, background): “Due to a lack of high resolution structural data the fate of the transmembrane and intracellular domains is still largely theoretical, but it is widely recognized that activation is achieved by separating the a and b cytoplasmic tails as a consequence of talin binding to b integrin membrane proximal”
- Integrin signalling at a glance (2009, background): “, 2003) – including Dok1 and integrincytoplasmic-domain-associated protein 1 (ICAP1) – and these can compete with talin for binding to integrin and so can impair activation (Millon-Fremillon et al., 2008; Wegener et al., 2007).”