Glutathione Homeostasis and Functions: Potential Targets for Medical Interventions

By V. Lushchak. Journal of Amino Acids, 2012

1,217 citations recorded by the source corpus.

Glutathione (GSH) is a tripeptide, which has many biological roles including protection against reactive oxygen and nitrogen species. The primary goal of this paper is to characterize the principal mechanisms of the protective role of GSH against reactive species and electrophiles. The ancillary goals are to provide up-to-date knowledge of GSH biosynthesis, hydrolysis, and utilization; intracellular compartmentalization and interorgan transfer; elimination of endogenously produced toxicants; involvement in metal homeostasis; glutathione-related enzymes and their regulation; glutathionylation of sulfhydryls. Individual sections are devoted to the relationships between GSH homeostasis and pathologies as well as to developed research tools and pharmacological approaches to manipulating GSH levels. Special attention is paid to compounds mainly of a natural origin (phytochemicals) which affect GSH-related processes. The paper provides starting points for development of novel tools and provides a hypothesis for investigation of the physiology and biochemistry of glutathione with a focus on human and animal health.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0a90f7f0953b36b5599973f99a4f4a97210465b6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Hanan Ahmed Hashem
2. M. C. Simon
3. Ankita Bansal

In Molecular Biology

1. Hanan Ahmed Hashem
2. M. C. Simon
3. Ankita Bansal
4. G. Semenza

Citations in the corpus

• Glutathione metabolism in cancer progression and treatment resistance (2018, background): “Apart from the classical antioxidant role, GSH also has several organelle-specific functions discussed in detail by Lushchak (2012).”
• Cadmium toxicity induces lipid peroxidation and alters cytokinin content and antioxidant enzyme activities in soybean (2014, background): “GSH is consumed by oxidation, conjugation, or hydrolysis, and it has been shown that GSH can be oxidized directly by ROS and RNS (reactive nitrogen species) or indirectly during GSH-dependent peroxidase-catalyzed reactions (Lushchak 2012).”
• Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “The modulation of cellular GSH is a double-edged sword, both sides of which have been exploited for potential therapeutic benefits [120].”