Glutathione metabolism and its implications for health.

By Guoyao Wu, Yun-Zhong Fang, Sheng Yang, J. Lupton, N. Turner. Journal of NutriLife, 2004

3,713 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7c54bf05c1fd7dcba65a2667c0d0acc78bf8a9ee

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In Biochemistry

In Rheumatology

Guoyao Wu

Citations in the corpus

Reduction-sensitive polymers and bioconjugates for biomedical applications. (2009, background): “Glutathione tripeptide (g-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight biological thiol and GSH/glutathione disulfide (GSSG) is the major redox couple in animal cells [9].”
NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, neutral): “oxidase and glutathione S-transferases (309).”
Important roles for the arginine family of amino acids in swine nutrition and production (2007, neutral): “…of NAG due to a reduced activity of mitochondrial NAG synthase is the unifying biochemical mechanism responsible for the limited intestinal synthesis of citrulline from both glutamine and proline and, therefore, for the primary cause of arginine deficiency in the neonates (Wu et al., 2004d).”
Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm (2005, neutral): “…extensive use that is made of parallel processing and advanced computer technology, and with the development of new intelligent search methods, the present two-step GAmethod is very robust, requires minimal operator intervention , and can be considered to be automated in the true sense of the word.”
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery. (2011, background): “The intracellular level of GSH is also dependent on other redox couples such as NADH/NAD, NADPH/NADP and thioredoxinred/thioredoxinox [9,10].”
Vitamin C physiology: the known and the unknown and Goldilocks (2016, neutral): “Glutathione is another intracellular reducing substance, often present at millimolar concentrations (Montero et al., 2013, Wu et al., 2004).”
Exercise-Induced Oxidative Stress: Cellular Mechanisms and Impact on Muscle Force Production (2008, background): “For a detailed discussion of nonenzymatic antioxidants, the reader is referred to numerous published reviews (97, 123, 177, 178, 184, 298, 303, 408).”
Functional amino acids and fatty acids for enhancing production performance of sows and piglets (2006, background): “Sci. 20(2):295-306 299 an important question of whether these nutrients play a crucial role in embryogenesis, angiogenesis, implantation, placental growth and development, blood flow, and fetal growth via modulation of intracellular protein turnover and cell proliferation (Wu et al., 2004a).”
Cardiac Metabolism and Its Interactions with Contraction, Growth, and Survival of the Cardiomyocte (2013, background): “The supply of NADPH from the PPP is important for antioxidant defense because NADPH is required for maintaining the level of reduced glutathione.(37) It has been shown that deficiency of G6P dehydrogenase (G6PD), the first and rate-limiting enzyme of the PPP, exacerbates ischemia–reperfusion injury ”
Endothelial dysfunction - a major mediator of diabetic vascular disease. (2013, background): “Mainly found in the reduced state, glutathione has numerous functions in metabolism, signal transduction and gene expression [156].”
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans (2017, background): “GSH is a tripeptide representing the most abundant nonprotein thiol present in the cell, where its concentration can reach the millimolar range [303, 304].”
Oxidative stress in the pathogenesis of skin disease. (2006, background): “In addition, l-buthionine-(S,R)-sulfoximine, an inhibitor of glutamate-cysteine ligase, has a similar effect (Wu et al., 2004).”
Metabolism Characteristics of Lactic Acid Bacteria and the Expanding Applications in Food Industry (2021, background): “As a natural antioxidant, glutathione is a tripeptide composed of glutamic acid, cysteine and glycine (Wu et al., 2004).”
Glutathione metabolism in cancer progression and treatment resistance (2018, background): “However, elevated levels of GSH in tumor cells are able to protect such cells in bone marrow, breast, colon, larynx, and lung cancers by conferring resistance to several chemotherapeutic drugs (Wu et al., 2004; Lu, 2009).”