Glutathione in Cancer Biology and Therapy
By J. Estrela, Á. Ortega, E. Obrador. Critical reviews in clinical laboratory sciences, 2006
985 citations recorded by the source corpus.
Subfields: Biochemistry, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/af982659c8c3f6a13acc096e93ef59b19b244736
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biochemistry
In Molecular Biology
- Subash C. Gupta
- Bharat B. Aggarwal
- Ralph J. Deberardinis
- Tzuling Cheng
- M. Chaturvedi
- Simone Reuter
- M. V. Vander Heiden
- C. V. Dang
Citations in the corpus
- Glutathione dysregulation and the etiology and progression of human diseases (2009, methodology): “…in the etiology and/or progression of a number of human diseases (Cerutti, 1985; Townsend et al., 2003; Liu et al., 2004; Ballatori et al., 2005; Estrela et al., 2006; Franco et al., 2007; Kinnula et al., 2007; Reynolds et al., 2007; Unauthenticated Download Date | 4/14/17 1:36 PM ( Slc25a11)…”
- Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “On the other hand, elevated GSH levels are observed in various types of cancerous cells and solid tumors, and this tends to make these cells and tissues more resistant to chemotherapy [91-93].”
- Antibody drug conjugate: the “biological missile” for targeted cancer therapy (2022, background): “The concentration of GSH in blood is considerably lower than intracellular concentration in cancer cells.(46) Therefore, this type of linker could keep stable in blood system while specifically release the active payloads in the cancer cells with an elevated GSH level.”
- Q's next: The diverse functions of glutamine in metabolism, cell biology and cancer (2009, background): “In tumors, maintaining a supply of GSH is critical for cell survival because it allows cells to resist the oxidative stress associated with rapid metabolism, DNA-damaging agents, inflammation and other sources (Estrela et al., 2006).”
- Role of Glutathione in Cancer Progression and Chemoresistance (2013, background): “Elevated GSH levels are observed in various types of tumors, and this makes the neoplastic tissues more resistant to chemotherapy [10, 11].”