Openings between defective endothelial cells explain tumor vessel leakiness.

By H. Hashizume, P. Baluk, S. Morikawa, J. Mclean, Gavin Thurston, S. Roberge, Rakesh K. Jain, D. McDonald. American Journal of Pathology, 2000

1,654 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/adf2a0bd0d8da6c4efd937c5d1de510a9669d376

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Citations in the corpus

Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. (2004, methodology): “Specimens measuring 1 to 3 mm on a side were cut from the slices, rinsed with 100 mmol/L cacodylate buffer, fixed with OsO4 (1% in 100 mmol/L cacodylate buffer at 4°C, 2 hours), rinsed with water, en bloc stained with uranyl acetate (2% aqueous for 48 hours at 38°C), dehydrated with acetone, and emb”
Liposomes as nanomedical devices (2015, background): “85,86 Liposomes can satisfy the size conditions needed to pass through tumor vessels and concentrate in the target site.”
The brain tumor microenvironment (2011, background): “Abnormalities in pericytes, particularly the dissociation of pericytes from the vasculature, contribute to increased tumor vascular permeability (Hashizume et al., 2000; Morikawa et al., 2002).”
Ligand-targeted therapeutics in anticancer therapy (2002, background): “Tumour vessels have an increased permeability to macromolecules owing to a lack of TIGHT JUNCTIONS between adjacent vasculature endothelial cell”
Molecular regulation of vessel maturation (2003, background): “As a result of the abnormal organization and ultrastructure of tumor vessels, the blood flow in tumor vessels is chaotic and the vessels are leak”
Delivering nanomedicine to solid tumors (2010, background): “and maximum pore diameters as large as several hundred nanometers ( Figure 1b )”
Endothelial cell functions (2003, background): “However, tumor vessels lack protection mechanisms that normal vessels acquire during growth, for example, they may lack functional pericytes and they are not always formed by a homogenous layer of endothelial cells (Hobbs et al., 1998; Hashizume et al., 2000; Morikawa et al., 2002).”
A Neurovascular Niche for Neurogenesis after Stroke (2006, methodology): “Using this process, the vascular anatomy of the peri-infarct cortex was defined by staining all endothelial cells with PECAM-1 and staining those that receive vascular perfusion with intravital administration of Lycopersicon esculentum (Hashizume et al., 2000).”
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, background): “The degree of leakiness of the endothelium and the enhanced vascular permeability to macromolecules and nanomaterials depend on many factors like the cancer type, its stage and in xenograft models, the implantation site of the tumor [44, 45, 58].”
Enhanced permeability and retention of macromolecular drugs in solid tumors: A royal gate for targeted anticancer nanomedicines (2007, background): “…have a relatively wide lumen, impaired functional receptors for AT II (Suzuki et al. 1981; Skinner et al. 1990; Hori et al. 1991; Li et al. 1993; Yuan et al 1995; Hashizume et al. 2000) and meager lymphatic drainage (Zeidman et al. 1955; Folkman 1971, 1995; Noguchi et al. 1998; Leu et al. 2000).”
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. (2002, methodology): “4] from a 18-gauge cannula inserted into the aorta via an incision in the left ventricle.(10) The fixative was not preceded by a saline rinse.”