Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors.

By S. Morikawa, P. Baluk, T. Kaidoh, A. Haskell, Rakesh K. Jain, D. McDonald. American Journal of Pathology, 2002

1,030 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/558861abc02bda8b6cd8b811e0e31a5648fb0aa8

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Citations in the corpus

Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. (2005, background): “We found that the β-gal+ cells did not colocalize with CD31+ ECs, although they often loosely surrounded small blood vessels, in agreement with the expected arrangement of pericytes in tumors (Morikawa et al., 2002).”
Rapid vascular regrowth in tumors after reversal of VEGF inhibition. (2006, background): “injection of fluorescent Lycopersicon esculentum lectin, which binds uniformly and rapidly to the luminal surface of the endothelium and thus labels patent blood vessels, and then staining the tumors for CD31 immunoreactivity (6, 33, 34).”
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. (2004, methodology): “Specimens measuring 1 to 3 mm on a side were cut from the slices, rinsed with 100 mmol/L cacodylate buffer, fixed with OsO4 (1% in 100 mmol/L cacodylate buffer at 4°C, 2 hours), rinsed with water, en bloc stained with uranyl acetate (2% aqueous for 48 hours at 38°C), dehydrated with acetone, and emb”
The brain tumor microenvironment (2011, background): “Abnormalities in pericytes, particularly the dissociation of pericytes from the vasculature, contribute to increased tumor vascular permeability (Hashizume et al., 2000; Morikawa et al., 2002).”
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. (2003, neutral): “We were motivated to investigate pericytes both by a report (28) and our unpublished data that pericytes were abundant in tumors of the RIP1Tag2 model.”
Tumor angiogenesis and vascular normalization: alternative therapeutic targets (2017, background): “Vessel permeability further reduces perfusion by causing blood leakage in upstream vessels [35] and increases fluid flux from the vascular to the interstitial space [43].”
Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? (2002, background): “and made up of a disorganized array of peri-endothelial PERICYTES and smooth-muscle cell”
Molecular regulation of vessel maturation (2003, background): “The data on the mural-cell coverage of tumor vessels is somewhat controversial, with some studies showing a paucity of mural cells and others showing their abundanc”
Accessories to the crime: functions of cells recruited to the tumor microenvironment. (2012, positive): “…and molecular programs are common to both physiological and tumor angiogenesis, constitutively activated proangiogenic signaling in tumors make tumor-associated vessels distinctly irregular, chaotic, and inherently unstable (De Bock et al., 2011; McDonald and Choyke, 2003; Morikawa et al., 2002).”
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Whereas pericytes are attracted to the tumor neovasculature by the same means as in developmental angiogenesis, pericyte investment of tumor blood vessels is clearly aberrant (Morikawa et al., 2002).”
Imaging of angiogenesis: from microscope to clinic (2003, background): “Nevertheless, when multiple markers are used for identification, pericytes are consistently found on tumor vessel”
The role of pericytes in blood-vessel formation and maintenance. (2005, background): “For example, pericytes in pancreatic islet tumors and glioblastomas appear to contain a higher number of ␣-SMA-positive pericytes than the respective normal tissue (Morikawa et al., 2002) (Figs.”
Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors (2004, methodology): “The mice were perfused and fixed with 4% paraformaldehyde, and 100- m-thick sections were prepared (13).”
Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target? (2013, background): “(23-25) Perivascular smooth muscle is often lacking in these vessels making them poorly reactive to stimuli.”