Molecular regulation of vessel maturation

By Rakesh K. Jain. Nature Medicine, 2003

2,605 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7ff47fd6ff8f7f24040b7c9875e96ab3b43da765

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Citations in the corpus

Friends or foes — bipolar effects of the tumour stroma in cancer (2004, background): “Fibronectin and collagen type IV were shown to have pro-angiogenic effects, through their ability to bind α 5 β 1 -integrin and α 1 β 1 -integrin (fibronectin), as well as α 2 β 1 -integrin (collagen type IV”
VEGF in Signaling and Disease: Beyond Discovery and Development (2019, background): “Understanding VEGF Biology in Cancer VEGF secreted by tumor cells and surrounding stroma stimulates the proliferation and survival of endothelial cells, leading to the formation of new blood vessels, which may be structurally abnormal and leaky (Ferrara, 2010a, 2010b; Jain, 2003; Nagy et al., 2009).”
The role of pericytes in blood-vessel formation and maintenance. (2005, background): “…several factors like S1P-1 (sphingosine-1- phosphate-1) and the angiopoietins have been implicated in the recruitment of pericytes and in vessel maturation (Jain, 2003), it is PDGF-B that appears to be the crucial player in the recruitment of pericytes to newly formed vessels (Betsholtz, 2004).”
Oxidative stress in angiogenesis and vascular disease. (2014, background): “These cells participate in a range of processes, such as cell adhesion, migration, proliferation, and differentiation, thereby adding another level of complexity.(4) Angiogenesis, either physiological or pathological, requires initiation by proangiogenic factors, exemplified by vascular endothelial ”
Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. (2007, background): “Whereas FGF-2 stimulated the proliferation of CD146+ cells, TGF-b1 inhibited it, consistent with the effects of these factors on mural cells (Hirschi and D’Amore, 1996; Jain, 2003).”
Vascular Endothelial Cell Biology: An Update (2019, background): “The capillary plexus is remodeled by sprouting, microvascular growth and fusion into a mature and functional vascular bed during angiogenesis [126,127].”
Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors (2004, background): “Ang2 has been shown to destabilize blood vessel (7), thus the reduction in Ang2 expression may contribute to a more stable vasculature as described above.”
Mesenchymal stem cells: revisiting history, concepts, and assays. (2008, background): “…stemness of these cells could be interpreted as a byproduct of a general developmental mechanism, whereby local cells committed to an organ-specific fate (e.g., myogenic in muscle, skeletogenic in BM) are recruited to nascent microvascular walls during development and postnatal growth (Jain, 2003).”