Liposomes as nanomedical devices
By Giuseppina Bozzuto, A. Molinari. International Journal of Nanomedicine, 2015
1,744 citations recorded by the source corpus.
Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. Liposomes are valued for their biological and technological advantages, and are considered to be the most successful drug-carrier system known to date. Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. Finally, we describe some strategies developed to overcome limitations of the “first-generation” liposomes, and liposome-based drugs on the market and in clinical trials.
Subfields: Biomaterials, Molecular Biology, Pharmaceutical Science
View Paper: https://www.semanticscholar.org/paper/857ed782c9c76d0c81cd1b500df088970efdf8bc
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In Biomaterials
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Citations in the corpus
- Liposomes: structure, composition, types, and clinical applications (2022, background): “Surfactants are single acyl-chain amphiphiles that destabilize the lipid bilayer of liposomal nanoparticles (Figure 7), thus increasing nano-vessel deformability [61, 62].”
- Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems (2023, background): “Consequently, the hydrophobic tails of the bilayer lie above each other and are often used to trap hydrophobic drugs while the aqueous core is used to entrap hydrophilic drugs [90].”
- Advances and Challenges of Liposome Assisted Drug Delivery (2015, background): “Furthermore, modifications of the lipid bilayer with charged lipids have also attracted much attention (Bozzuto and Molinari, 2015).”