IL-23 promotes tumour incidence and growth

By J. Langowski, Xueqing Zhang, Lingling Wu, J. Mattson, Taiying Chen, Kathy Smith, Beth Basham, T. Mcclanahan, R. Kastelein, M. Oft. Nature, 2006

1,013 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/adec61527e366e035ba4578e4c8e109e54de5e48

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Citations in the corpus

Th17 cells promote cytotoxic T cell activation in tumor immunity (2009, background): “In contrast to our results, IL-23, important in Th17 cell regulation, has been shown to promote tumor growth and prevent immunosurveillance (Langowski et al., 2006).”
Immunity, Inflammation, and Cancer (2010, neutral): “…subsets found in solid tumors are involved in tumor promotion, progression, or metastasis, including CD8+ T cells (Roberts et al., 2007), IFNγ-producing Th1 cells (Hanada et al., 2006), Th2 cells (Aspord et al., 2007; DeNardo et al., 2009) and Th17 cells (Langowski et al., 2006; Wang et al., 2009).”
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer (2009, background): “In recent years, an important protumorigenic role for IL-23 has also emerged (94).”
Cancer-related inflammation: common themes and therapeutic opportunities. (2012, background): “For nstance, IL-1 is involved in the generation of IL-17 producing CD+ T ells and the IL-23/IL-17 axis has been shown to promote skin carinogenesis [61].”
The IL-17 family of cytokines in health and disease (2019, background): “In addition, as discussed above, IL-17 promotes proliferation of skin epithelial cells to promote tumorigenesis (Chen et al., 2019; Langowski et al., 2006).”
IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway (2009, background): “…role of the immune system in tumor immune surveillance and cancer promotion is exemplified by a pair of related cytokines: although IL-12 clearly possesses antitumor activity via both NK activation and Th1/IFN- induction, IL-23 has been found to promote carcinogenesis (Langowski et al., 2006).”
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. (2007, background): “Indeed, we show that IL-23 is significantly upregulated in the overwhelming majority of human carcinoma samples (43).”
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, neutral): “as IL-1β, IL-6 and TNF-α [11-14].”