Serotonin, tryptophan metabolism and the brain-gut-microbiome axis.

By S. O'Mahony, G. Clarke, Y. Borre, Ted G. Dinan, J. Cryan. Behavioural Brain Research, 2015

1,777 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Gastroenterology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ada9278c04f210532eab37b4113fc36027dcc39f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. C. Stanton
6. S. Mazmanian
7. Ygor P. Silva
8. A. Bernardi

In Gastroenterology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. C. Stanton
6. Ygor P. Silva
7. A. Bernardi
8. R. Frozza

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. T. Sampson
6. S. Mazmanian
7. C. Stanton
8. Ygor P. Silva

Citations in the corpus

• Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “The gut microbiota may influence host Trp degradation and circulating Trp concentrations through KP (O’mahony et al., 2015).”
• Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health (2017, background): “N. C. D’Amato et al., A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer.”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “…et al., 2015; Zijlmans et al., 2015) and psychological stress (Bailey et al., 2011; Bharwani et al., 2016; Galley et al., 2014; Reber et al., 2016) As outlined above and elsewhere in this issue, glucocorticoids modulate the expression of TDO (O'Farrell and Harkin, 2015; O’Mahony et al., 2015).”
• Control of Brain Development, Function, and Behavior by the Microbiome (2015, neutral): “is capable of crossing the BBB, where it can then participate in 5-HT synthesis (O’Mahony et al., 2015; Sharon et al., 2014).”
• Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis (2016, background): “A balance is needed between bacterial utilization of tryptophan and the tryptophan necessary for serotonin synthesis in both enteric and central nervous systems [101].”
• Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. (2016, background): “…hypothalamic-pituitary-adrenal axis (HPA) activity (Sudo et al., 2004), altered tryptophan metabolism (Clarke et al., 2013; El Aidy et al., 2012; O'Mahony et al., 2015; Yano et al., 2015), neurotrophic factors (Bercik et al., 2011), and neurogenesis (M€ohle et al., 2016; Ogbonnaya et al., 2015).”
• The Central Nervous System and the Gut Microbiome (2016, background): “…et al., 2015; Matcovitch-Natan et al., 2016), myelination (Gacias et al., 2016; Hoban et al., 2016) and expression of neurotrophins (Bercik et al., 2011a, 2011b; Desbonnet et al., 2015), neurotransmitters (Bercik et al., 2011a; O’Mahony et al., 2015), and their respective receptors. animal models.”
• Mitochondrial dysfunction: mechanisms and advances in therapy (2024, background): “402 Supplementing mitochondria decreased the IDO activity and attenuated anxiety-and depression-like behaviors, highlighting the potential to treat psychiatric disorders.”
• Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, background): “The hypothalamic–pituitary–adrenal (HPA) axis, which provides the core regulation of the stress response, can significantly impact the microbiota–gut–brain axis (O’Mahony et al. 2009, 2011, 2015b; Scott et al. 2013; Moloney et al. 2014; Tillisch, 2014; Wang & Kasper, 2014).”
• The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “Tryptophan is also metabolized via the kynurenine pathway (KP), which can lead to the production of nicotinamide adenosine dinucleotide (NAD+) (168), as well as quinolic and kynurenic acid.”
• Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain. (2019, background): “On the one hand, tryptophan serves as a sole precursor for the biosynthesis of the neuroendocrine transmitter serotonin and, subsequently, a pineal hormone called melatonin (21); on the other hand, tryptophan in the host can be degraded through the kynurenine pathway (22).”
• The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “Microorganisms can influence CNS processes bidirectionally via the vagus nerve (12) and through modulation of the immune system (6), the hypothalamic-pituitary-adrenal (HPA) axis (13, 14), and tryptophan metabolism (15), along with their ability to synthetize a number of neurotransmitters (16–18) an”