Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis
By T. Jenkins, Jason C. D. Nguyen, K. Polglaze, P. Bertrand. Nutrients, 2016
786 citations recorded by the source corpus.
The serotonergic system forms a diffuse network within the central nervous system and plays a significant role in the regulation of mood and cognition. Manipulation of tryptophan levels, acutely or chronically, by depletion or supplementation, is an experimental procedure for modifying peripheral and central serotonin levels. These studies have allowed us to establish the role of serotonin in higher order brain function in both preclinical and clinical situations and have precipitated the finding that low brain serotonin levels are associated with poor memory and depressed mood. The gut-brain axis is a bi-directional system between the brain and gastrointestinal tract, linking emotional and cognitive centres of the brain with peripheral functioning of the digestive tract. An influence of gut microbiota on behaviour is becoming increasingly evident, as is the extension to tryptophan and serotonin, producing a possibility that alterations in the gut may be important in the pathophysiology of human central nervous system disorders. In this review we will discuss the effect of manipulating tryptophan on mood and cognition, and discuss a possible influence of the gut-brain axis.
Subfields: Biological Psychiatry, Gastroenterology, Physiology
View Paper: https://www.semanticscholar.org/paper/379186311151dceddda2dc8c86793162e0cf4193
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Citations in the corpus
- The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology (2020, background): “A potential role of dysbiosis has been suggested as cause of these mood and behavioral defects (55), however, the exact mechanism behind these phenomena still needs to be understood.”
- Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism (2018, background): “…the gut microbiome composition, which may directly affect downstream metabolism and immunoregulatory pathways; the composition of gut bacteria can thus regulate Trp metabolism and the availability of Trp and Trp metabolites (Jenkins et al., 2016), influencing the immune response in the gut.”