Control of Brain Development, Function, and Behavior by the Microbiome

By T. Sampson, S. Mazmanian. Cell Host and Microbe, 2015

981 citations recorded by the source corpus.

Animals share an intimate and life-long partnership with a myriad of resident microbial species, collectively referred to as the microbiota. Symbiotic microbes have been shown to regulate nutrition and metabolism, and are critical for the development and function of the immune system. More recently, studies have suggested that gut bacteria can impact neurological outcomes – altering behavior and potentially affecting the onset and/or severity of nervous system disorders. In this review, we highlight emerging evidence that the microbiome extends its influence to the brain via various pathways connecting the gut to the central nervous system. While understanding and appreciation of a gut microbial impact on neurological function is nascent, unraveling gut-microbiome-brain connections holds the promise of transforming the neurosciences and revealing potentially novel etiologies for psychiatric and neurodegenerative disorders.

Subfields: Biological Psychiatry, Molecular Biology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/a3c8a01cbad4916bea7872fea83c0a055eaca07a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. J. Foster
5. L. Rinaman
6. C. Stanton
7. R. Stilling
8. E. Gomaa

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. J. Foster
6. L. Rinaman
7. R. Stilling
8. M. van de Wouw

In Social Psychology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. C. Stanton
5. R. Stilling
6. J. Foster
7. L. Rinaman
8. E. Gomaa

Citations in the corpus

• New evidences on the altered gut microbiota in autism spectrum disorders (2017, background): “Since the gut microbiota makes critical contributions to metabolism and maintenance of immune homeostasis and may control the central nervous system (CNS) activities through neural, endocrine, and immune pathways [9], it has been hypothesized the active role of the gut microbiota in ASD pathophysiol”
• Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration (2017, background): “There is an emerging consensus, at least from animal studies, that the gut microbiota plays a pivotal role in regulating early brain development (Bercik et al. 2012; Collins et al. 2012; Mayer et al. 2014a; Borre et al. 2014; Sampson & Mazmanian, 2015).”
• Human gut microbiota/microbiome in health and diseases: a review (2020, background): “Phages have a great therapeutic potential that they could be used either for antimicrobial purposes or to modulate the composition of microbial communities (Scarpellini et al. 2015).”
• Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice (2017, background): “In addition, age, therapy, and neurological condition (10) might also affect the gut microbial composition.”
• Impact of Omega-3 Fatty Acids on the Gut Microbiota (2017, background): “Indeed, the gut microbiota is an integral part of the microbiota–gut–brain axis, a bidirectional crosstalk between the gut microbiota and brain, essential in the regulation of many physiological functions, such as digestive and gastrointestinal functions, as well as inflammation, neurogenesis, neuro”
• Stress & the gut-brain axis: Regulation by the microbiome (2017, background): “8 As mentioned above, the experimental use of GF mice has been instrumental in revealing the impact of microbiota on early brain d evelopment [28, 50, 51].”
• The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis? (2016, background): “As such, central nervous system function and subsequently also human and animal behaviour is influenced by microbial presence, metabolism and activity (Collins et al., 2012; Cryan and Dinan, 2012; Mayer et al., 2014; Sampson and Mazmanian, 2015).”