Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration

By Ted G. Dinan, J. Cryan. Journal of Physiology, 2017

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Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome (2018, background): “Changes in the composition of intestinal bacterial populations are associated with a wide array of neurological and neurodevelopmental disorders including multiple sclerosis, autism, depression, schizophrenia, and Parkinson’s disease[70-72].”
The Gut Microbiota and Alzheimer’s Disease (2017, neutral): “Recent studies suggest that the gut microbiota plays a pivotal role in the modulation of gut and brain functions (for review, see [10, 12–14]).”
Brain-Gut-Microbiota Axis in Alzheimer’s Disease (2019, background): “the key role of gut microbiota in early brain development and adult neurogenesis.(1,2) In the elderly, hyperstimulation of the immune system results in chronic, low-grade state of inflammation (“inflammaging”).”
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020, background): “Although the precise mechanisms involved in the action of SCFAs on the CNS remain largely unknown, a multitude of animal studies have shown that they exert widespread influence on key neurological and behavioral processes and may be involved in critical phases of neurodevelopmental and neurodegenera”
Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis (2019, neutral): “complex interaction mainly occurs in hippocampus [95, 96].”