Cancer as a metabolic disease

By T. Seyfried, Laura M. Shelton. Nutrition and Metabolism, 2010

720 citations recorded by the source corpus.

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8c85899a23f9d980b134d03b64ee7e90bae8d6f1

How researchers see this paper

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In Cancer Research

1. U. Ndagi
2. Mahmoud E. S. Soliman
3. N. Mhlongo

In Molecular Biology

1. U. Ndagi
2. Mahmoud E. S. Soliman
3. N. Mhlongo

Citations in the corpus

• Metal complexes in cancer therapy – an update from drug design perspective (2017, positive): “75 For example, 2 αα ,3-diaminosugars complexes analogous to oxaliplatin were investigated and found to have promising activity.”