Medulloblastoma Growth Inhibition by Hedgehog Pathway Blockade

By David M. Berman, S. S. Karhadkar, A. Hallahan, Joel I. Pritchard, C. Eberhart, D. N. Watkins, James Chen, M. K. Cooper, Jussi Taipale, J. Olson and 1 more. Science, 2002

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Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours (2003, neutral): “As previously reported for shorter treatment course”
Hedgehog signalling in cancer formation and maintenance (2003, background): “Target genes and interactions Recent studies mark Hh signalling as a key contributor to cancer formation and maintenance in a distinct but restricted set of cell type”
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer (2003, background): “, and inhibits the malignant growth of medulloblastoma cells lacking Ptch functio”
Communicating with Hedgehogs (2005, background): “Small molecule activators and inhibitors of Hh signalling are currently being developed for the treatment of Hh-related pathologie”
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. (2002, background): “As a specific Smo antagonist, cyclopamine may be generally useful in the treatment of 2746 GENES & DEVELOPMENT such cancers, a therapeutic strategy further supported by the absence of observable toxicity in cyclopaminetreated animals (Keeler and Binns 1968; Berman et al. 2002).”
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis (2003, background): “Cyclopamine, a steroidal alkaloid that inhibits Hh signalling through direct interaction with Sm”