Hedgehog signalling in cancer formation and maintenance

By M. Magliano, Matthias Hebrok. Nature Reviews. Cancer, 2003

871 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/9e0023525fbbabd8010b5d4ab656f51a770559fb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Alec C. Kimmelman
2. N. Bardeesy
3. R. DePinho
4. M. Scott
5. David M. Gonzalez
6. D. Medici
7. J. Hooper
8. David M. Sabatini

Citations in the corpus

• Communicating with Hedgehogs (2005, background): “Increased Hh signalling in some organs can lead to cancers — of the skin, cerebellum, muscle, digestive tract, pancreas or prostat”
• Genetics and biology of pancreatic ductal adenocarcinoma. (2006, background): “Alterations that activate this pathway, including loss of PTC, activating mutations in SMO, and overexpression of GLI and HH proteins, have been implicated in a variety cancers (for reviews on Hedgehog signaling and cancer, see Taipale and Beachy 2001; Pasca di Magliano and Hebrok 2003).”
• Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Oncogenic forms of Shh have been identified in basal cell carcinoma and are misregulated in prostate adenocarcinoma, esophageal and stomach cancer, and pancreatic adenocarcinoma (201).”