A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene

By R. Duerr, K. Taylor, S. Brant, J. Rioux, M. Silverberg, M. J. Daly, A. Steinhart, C. Abraham, M. Regueiro, A. Griffiths and 13 more. Science, 2006

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IL-17 and Th17 Cells. (2009, background): “R381Q) conferred strong protection from Crohn’s disease, whereas several variants in the noncoding region of this gene were associated with increased susceptibility to Crohn’s disease (92).”
The IL-17 family of cytokines in health and disease (2019, background): “The so-called “IL-23-IL-17 axis” was found to function as a critical driver of autoimmune disease, first in mouse models lacking either IL-23 or IL-17, and later validated in humans by genome wide association studies (GWAS) and eventually by clinical blockade of these cytokines in autoimmunity (Duer”
Privacy-Preserving Data Exploration in Genome-Wide Association Studies (2013, background): “A study may report individual correlations between SNP pairs of interest [5, 27], or a “heat map” of the correlations among all SNPs in a region [5, 13, 27, 28, 34].”