Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

By B. Mao, Wei Wu, G. Davidson, J. Marhold, Mingfa Li, B. Mechler, H. Delius, Dana Hoppe, P. Stannek, Carmen Walter and 2 more. Nature, 2002

973 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a9ae1cd31f9baf03da3b94b4450c17f325b768fd

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Hans Clevers
2. R. Nusse
3. Jeffrey L. Wrana
4. Christof Niehrs
5. W. Birchmeier
6. C. Roy
7. L. Bonewald

In Molecular Biology

1. Hans Clevers
2. R. Nusse
3. Christof Niehrs
4. Xi He
5. W. Birchmeier
6. K. Tamai
7. C. Logan
8. J. Smolen

Citations in the corpus

• The Wnt signaling pathway in development and disease. (2004, background): “It binds to LRP with high affinity (Bafico et al. 2001, Mao et al. 2001a, Semenov et al. 2001) and to another class of transmembrane molecules, the Kremens (Mao & Niehrs 2003, Mao et al. 2002).”
• Wnt signalling and its impact on development and cancer (2008, background): “An additional DKK-receptor, Kremen , was shown to inhibit the Wnt signalling pathway by internalization of LR”
• Inflammatory bone loss: pathogenesis and therapeutic intervention (2012, background): “DKK1 binds to LRP4, LRP5 or LRP6 by utilizing a co-receptor, Kremen 1 (also known as the Dickkopf receptor) or Kremen 2, to form a ternary complex that is endocytosed, thus eliminating LRP from the cell surface and preventing it from binding to WN”
• Wnt/beta-catenin signaling in development and disease. (2006, positive): “Through this interaction, Dkk1 crosslinks LRP6 to another class of transmembrane molecules, the Kremens (Mao et al., 2002), thus promoting the internalization and inactivation of LRP6.”
• Osteocytes, mechanosensing and Wnt signaling. (2008, background): “The tertiary complex that is formed is internalized and thus lrp5 is removed from the cell surface and unable to bind Wnt (78).”
• Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling (2005, background): “pl?Q8NCW0">Kremen-2 , blocks Wnt/β-catenin signalling, and induces the internalization and clearance of cell-surface LRP6 (Ref”
• Dorsal-ventral patterning and neural induction in Xenopus embryos. (2004, background): “The resulting trimolecular complex of LRP5/6, Dkk, and Kremen is endocytosed, resulting in the depletion of LRP5/6 coreceptor from the plasma membrane (Mao et al. 2002).”
• Dickkopf-1 is a master regulator of joint remodeling (2007, background): “Several members of the Wnt protein family bind a receptor complex (consisting of LPR5/6 and frizzled receptors) on the plasma membrane of mesenchymal cells, which signals osteoblast differentiation by engaging the intracellular protein β-cateni”
• Sex differences in human adipose tissues – the biology of pear shape (2012, background): “Both KREMEN1 and RSPO3 interact with the Wnt signaling pathway, which in turn plays a fundamental role in adipocyte differentiation [62,63].”
• Function and biological roles of the Dickkopf family of Wnt modulators (2006, background): “There are no Krm homologs in Drosophila, but heterologous expression of vertebrate Dkk1 and Krm2 together, but not either gene alone, results in inhibition of Wg signaling in the fly wing (Mao et al., 2002).”