Osteocytes, mechanosensing and Wnt signaling.

By L. Bonewald, Mark L. Johnson. Bone, 2008

1,084 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/89623a68a1537b197a3bfa84e6134e6ea26d0e1f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Jay J Cao
2. J. Smolen
3. K. Redlich
4. L. Bonewald

In Molecular Biology

1. J. Smolen
2. Jay J Cao
3. R. Florêncio-Silva
4. E. Sasso-Cerri
5. M. Simões
6. G. R. S. Sasso
7. P. Cerri
8. K. Redlich

Citations in the corpus

• Effects of obesity on bone metabolism (2011, background): “Mechanical loading stimulates bone formation by decreasing apoptosis and increasing proliferation and differentiation of osteoblasts and osteocytes [56] through the Wnt/b-catenin signaling pathway [ 57 ,58].”
• The influence of bone surface availability in bone remodelling: A mathematical model including coupled geometrical and biomechanical regulations of bone cells (2012, methodology): “ruse is believed to increase bone formation by stimulating Wnt signalling to pre-osteoblasts, which increases their proliferation and ultimately leads to an increased population of active osteoblasts [22,30]. In the model, this is implemented using a mechanically controlled proliferation of pre-oste”
• Oxidative stress in bone remodeling: role of antioxidants. (2017, background): “ROS induce the apoptosis of osteoblasts and osteocytes, cells localized in the bone matrix and derived from mature osteoblasts, thus favouring osteoclastogenesis (19, 30, 31, 41, 42) (Figure 1).”
• The Amazing Osteocyte (2010, background): “Therefore, the Wnt/b-catenin signaling pathway plays a role not only in bone response to loading but also in osteocyte apoptosis.((58))”
• Inflammatory bone loss: pathogenesis and therapeutic intervention (2012, background): “Some osteoblasts develop into lining cells that cover bone surface”
• Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015, background): “On the other hand, mechanical unloading downregulates anabolic factors and stimulates osteocytes to produce sclerostin and DKK-1, which are inhibitors of osteoblast activity [185–188], as well as specific factors that stimulate local osteoclastogenesis [189].”