Efflux-mediated antimicrobial resistance.

By K. Poole. Journal of Antimicrobial Chemotherapy, 2005

1,096 citations recorded by the source corpus.

Subfields: Genetics, Molecular Medicine, Pollution

View Paper: https://www.semanticscholar.org/paper/a93828b7c15c4419da16a8a37a11890b9fc40c79

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. L. Piddock
2. Xian-Zhi Li
3. J. Pagés
4. E. Peterson
5. P. Kaur
6. F. Codjoe
7. Isabel Sá-Correia
8. Jo Handelsman

In Molecular Medicine

1. H. Nikaido
2. Xian-Zhi Li
3. D. Hooper
4. Ari Robicsek
5. G. Jacoby
6. J. Pagés
7. E. Peterson
8. P. Kaur

In Pollution

1. Xian-Zhi Li
2. E. Peterson
3. P. Kaur
4. F. Codjoe
5. L. Piddock
6. E. Donkor
7. D. Hooper
8. Moushumi Tabassoom Salam

Citations in the corpus

• The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria (2008, background): “Here, we focus on the influx of antibiotics, as the efflux has been extensively discussed in recent review”
• How to manage Pseudomonas aeruginosa infections (2018, background): “Noteworthy, quinolones are substrates of all efflux systems and represent an important triggering factor that may generate cross-resistance towards several important classes of antibiotics for pseudomonal treatment, including β-lactams and aminoglycosides [41,44].”
• Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria (2006, background): “Which of the clinically relevant agents, then, are typically affected by bacteria that overexpress MDR efflux pumps? There have been several keynote publications in this field in recent years describing the various classes of efflux pumps and their substrates, structures, and functions (19, 63, 96, ”
• Global Challenge of Multidrug-Resistant Acinetobacter baumannii (2007, neutral): “the resistance-nodulation-cell division family (153).”
• Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens (2018, background): “However, examples of multidrug/polyspecific exporters have been found in each of these five families (Poole, 2005; Schindler and Kaatz, 2016), suggesting that polyspecificity is widely distributed and must be an ancient phenomenon.”
• Resistance of bacterial biofilms to disinfectants: a review (2011, background): “Similar systems have been identified in other species and also for other biocides such as triclosan or chlorhexidine (Poole 2005; Villagra et al. 2008).”
• Carbapenem Resistance: A Review (2017, background): “One of the structures of drug-efflux pump systems extensively reviewed by Poole [45] was MexAB-OprM.”
• Lipopolysaccharide modification in Gram-negative bacteria during chronic infection. (2016, background): “…by the host immune system (Smith et al. , 2006), increased activity of efflux pumps associated with antibiotic resistance, especially against those antibiotics used clinically (Poole, 2005), and a switch from non mucoid to mucoid phenotypes (Ciofu et al. , 2010, Hogardt & Heesemann, 2010).”
• Antimicrobial Resistance: A Growing Serious Threat for Global Public Health (2023, background): “Instead, genes for substrate-specific efflux pumps (for example those for chloramphenicol, tetracyclines, and macrolides) are more likely to be found on mobile genetic elements [38,49].”
• Call of the wild: antibiotic resistance genes in natural environments (2010, background): “Certain classes of efflux pumps, for example, offer general mechanisms of resistance, because they pump various toxins, such as heavy metals and other toxic molecules, out of cell”
• Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents (2017, background): “To drive antimicrobial agent efflux, the ABC family system hydrolyses ATP, whereas the MF family, MATE family, and the RND family functions as secondary transporters, catalyzing drug ion antiproton (H+ or Na+) [74].”
• Multidrug Resistance in Bacteria (2009, background): “Contributions of RND efflux pumps to the resistance in clinical strains—RND pumps are making major contributions both to the intrinsic and elevated resistance of clinically relevant pathogens (48).”
• Structure, Function, and Evolution of Bacterial ATP-Binding Cassette Systems (2008, background): “Efflux systems are now thought to play an important role in bacterial drug resistance (278, 288, 372).”
• Plasmid-Mediated Quinolone Resistance: a Multifaceted Threat (2009, background): “Efflux determinants of quinolone resistance in gram-negative bacteria are largely multidrug transporters of the resistance-nodulation-cell division (RND) family encoded by endogenous chromosomal genes (159).”