Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria

By L. Piddock. Clinical Microbiology Reviews, 2006

1,185 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/601fff41c3c5c7dd34d0686bf91a8b301627b7dd

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Citations in the corpus

An overview of the antimicrobial resistance mechanisms of bacteria (2018, background): “The RND family are multi-component pumps (found almost exclusively in gram negative bacteria) that function in association with a periplasmic membrane fusion protein (MFP) and an outer membrane protein (OMP-porin) to efflux substrate across the entire cell envelope [28,29,73,74].”
The antibiotic resistome: the nexus of chemical and genetic diversity (2007, background): “aeruginosa that are normally found in various environments (soil and fresh water) have a remarkable collection of efflux pump”
Acinetobacter baumannii: Emergence of a Successful Pathogen (2008, background): “Unfortunately, progress has been slow, with agents such as phenyl-arginine-naphthylamide doing well when assessed in vitro but coming to demise due to toxicity concerns (433).”
Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations. (2014, background): “Substrate profiles of other clinically relevant pathogens are reviewed elsewhere [6,14].”
Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence (2019, background): “Clinical resistance is usually the result of mutational events leading to increased pump expression or improved pump effectiveness (Piddock 2006a, b).”
Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “as well as Enterobacteriaceae often possess this type of mechanism in addition to drug efflux systems.([1,6,18,24]) A Salmonella enterica serovar Waycross isolate, obtained from a hospitalized elderly, possesses plasmidborne class 1 integron harbouring resistance genes blaIMP-4 (encoding for a class”