The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

By J. Pagés, Chloe E. James, M. Winterhalter. Nature Reviews Microbiology, 2008

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Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “Recently, several reviews that focus on various aspects of the drug efflux transporters or MDR have been published.([3-10])”
Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives (2021, background): “Antibiotics influx is mainly controlled by porins which are proteins able to form water-filled open channels that allowing the passive transportation of molecules across lipid bilayer membranes [66].”
Understanding the Mechanism of Bacterial Biofilms Resistance to Antimicrobial Agents (2017, background): “coli), Enterobacteraerogenes and Klebsiella pneumonia, the efflux pump slows down the penetration of hydrophilic solutes that decrease the transmembrane diffusion of lipophilic solutes by down-regulating the ‘porin’ production [70, 71].”
Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “Omp36-producing strains typically exhibit intermediate carbapenem susceptibility profiles, while those lacking both porins show carbapenem resistance (233, 235, 236).”
All-atom 3D structure prediction of transmembrane β-barrel proteins from sequences (2015, background): “These roles include outer-membrane protein biogenesis (3, 4), antibiotic resistance (5), vaccine design, translocation of virulence factors, and the design of cancer therapeutics (6).”