Multidrug Resistance in Bacteria

By H. Nikaido. Annual Review of Biochemistry, 2009

1,621 citations recorded by the source corpus.

Large amounts of antibiotics used for human therapy, as well as for farm animals and even for fish in aquaculture, resulted in the selection of pathogenic bacteria resistant to multiple drugs. Multidrug resistance in bacteria may be generated by one of two mechanisms. First, these bacteria may accumulate multiple genes, each coding for resistance to a single drug, within a single cell. This accumulation occurs typically on resistance (R) plasmids. Second, multidrug resistance may also occur by the increased expression of genes that code for multidrug efflux pumps, extruding a wide range of drugs. This review discusses our current knowledge on the molecular mechanisms involved in both types of resistance.

Subfields: Molecular Medicine, Oncology, Pollution

View Paper: https://www.semanticscholar.org/paper/e16273179467c60b684c073f10f012a5a1a7c2fc

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Citations in the corpus

Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. (2013, background): “ing genetic aspects of antimicrobial resistance in aquatic bacteria strongly suggests that antimicrobial use in aquaculture is also likely to select antimicrobial-resistant bacteria (including piscine pathogens) in aquacultural environments (Aarestrup et al., 2000; Cabello, 2006; Nikaido, 2009; Levy”
Multidrug Resistance: An Emerging Crisis (2014, neutral): “Studies from WHO report have shown very high rates of resistance (Table 1) in bacteria such as Escherichia coli against antibiotics as cephalosporin and fluoroquinolones, Klebsiella pneumoniae against cephalosporin and carbapenems, Staphylococcus aureus againstmethicillin, Streptococcus pneumoniae a”
Bacillus subtilis A Potential Probiotic Bacterium to Formulate FunctionalFeeds for Aquaculture (2014, background): “Synthetic antibiotics was the first option to control pathogens overgrowth in humans and animals, however the unregulated use of these compounds induced a multi-resistant mechanisms preferentially developed by the pathogenic bacteria [30].”
Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens (2018, background): “In fact, plasmids can carry a collection of resistance genes as part of transposons, thus simultaneously conferring resistance to several classes of antibiotics and metal ions (Nikaido, 2009).”
Pseudomonas syringae pv. actinidiae: chemical control, resistance mechanisms and possible alternatives (2014, background): “These systems are known to be important for multidrug resistance in Gram-negative bacteria (Nikaido, 2009).”
Efflux-Mediated Drug Resistance in Bacteria: an Update (2009, background): “In this article, we cover the advances in bacterial efflux systems since 2003 with emphasis on the clinical relevance of the drug exporters 1556 Li & Nikaido ª 2009 Adis Data Information BV.”
Antibiotic resistance and its cost: is it possible to reverse resistance? (2010, background): “The most common mutations lead to alterations in the antibiotic target and increases in drug efflu”
The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “Multidrug resistance in bacteria may be generated by one of two mechanisms (Nikaido 2009).”