Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

By Yong Son, Y. Cheong, Nam‐Ho Kim, Hun-taeg Chung, D. Kang, H. Pae. Journal of signal transduction, 2011

1,144 citations recorded by the source corpus.

Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases that play the major role in signal transduction from the cell surface to the nucleus. MAPKs, which consist of growth factor-regulated extracellular signal-related kinases (ERKs), and the stress-activated MAPKs, c-jun NH2-terminal kinases (JNKs) and p38 MAPKs, are part of a three-kinase signaling module composed of the MAPK, an MAPK kinase (MAP2K) and an MAPK kinase (MAP3K). MAP3Ks phosphorylate MAP2Ks, which in turn activate MAPKs. MAPK phosphatases (MKPs), which recognize the TXY amino acid motif present in MAPKs, dephosphorylate and deactivate MAPKs. MAPK pathways are known to be influenced not only by receptor ligand interactions, but also by different stressors placed on the cell. One type of stress that induces potential activation of MAPK pathways is the oxidative stress caused by reactive oxygen species (ROS). Generally, increased ROS production in a cell leads to the activation of ERKs, JNKs, or p38 MAPKs, but the mechanisms by which ROS can activate these kinases are unclear. Oxidative modifications of MAPK signaling proteins and inactivation and/or degradation of MKPs may provide the plausible mechanisms for activation of MAPK pathways by ROS, which will be reviewed in this paper.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/78920489785f35ae1e11e57e7c2e9032075e4a6d

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In Immunology

1. Liying Wang
2. Y. Rojanasakul
3. Amruta Manke
4. E. Kurutaş

In Molecular Biology

1. Liying Wang
2. Y. Rojanasakul
3. Amruta Manke
4. E. Kurutaş

Citations in the corpus

• Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity (2013, background): “Finally, the site of ROS production and the concentration and kinetics of ROS production as well as cellular antioxidant pools and redox state are most likely to be important factors in determining the effects of ROS on activation ofMAPKpathways [107].”
• The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state (2015, background): “reported that hydrogen peroxide inactivates MKPs by oxidation of their catalytic cysteine, which leads to sustained activation of the MAPK pathway [134].”