Regulation of immune responses by L-arginine metabolism

By V. Bronte, Paola Zanovello. Nature reviews. Immunology, 2005

1,814 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/76c8340a298bc7e91c09ef252d13f3e6fa341676

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In Immunology

Citations in the corpus

Myeloid derived suppressor cells promote cross-tolerance in B cell lymphoma by expanding regulatory T cells (2008, background): “suppress the tumor-specific T-cell response by mechanisms requiring TGF-h secretion (19), arginase induction (25, 33), and/ or NO production (21).”
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases (2015, background): “Specifically, both Arg1 and induced nitric oxide synthase (iNOS) expressed in the CNS utilize arginine as the sole substrate for biosynthetic pathways [37, 39].”
Human nutrition, the gut microbiome, and immune system: envisioning the future (2011, background): “Withdrawal of tryptophan and arginine controls immune response”
Amino acids and immune function (2007, background): “…in macrophages and neutrophils is an essential mechanism against viruses, bacteria, fungi, malignant cells, intracellular protozoa, and parasites in mammals, birds, terrestrial animals, low vertebrates (e.g. freshwater and marine fishes) and invertebrates (e.g. shrimp) (Bronte & Zanovello, 2005).”
Tumor-induced tolerance and immune suppression depend on the C/EBPbeta transcription factor. (2010, background): “of C/EBPb caused a significant reduction in both arginase 1 (Arg1) and nitric oxide synthase 2 (Nos2) proteins (Figure 6A), two enzymes that were described as crucial components of MDSC inhibitory machinery (Bronte and Zanovello, 2005; Gabrilovich and Nagaraj, 2009).”
Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells (2008, background): “Moreover, in an L-arginine-deficient environment MDSC-expressing NOS2 promotes RNS and ROS production, as seen in the previous stage but in a larger scale and without the intervention of NADPH oxidase (85).”
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives (2008, background): “In the late 1980s, Albina and Mills (26, 62) demonstrated that L-Arg was fundamental for wound healing processes possibly by increasing the production of proline and collagen.”
Amino acids: metabolism, functions, and nutrition (2009, background): “It is noteworthy that a large amount of NO synthesized from arginine by inducible NO synthase is cytotoxic to pathogenic microorganisms and viruses (Bronte and Zanovello 2005).”
Functional amino acids and fatty acids for enhancing production performance of sows and piglets (2006, background): “Of note, a large amount of NO synthesized from arginine by inducible NO synthase is cytotoxic to pathogenic microorganisms and virus (Bronte and Zanovello, 2005).”
Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens (2008, background): “Although macrophage Arg1 expression is commonly linked to the hypothesized antiworm functions of alternatively activated macrophages (AAMs”
INTERLEUKIN-4- AND INTERLEUKIN-13-MEDIATED ALTERNATIVELY ACTIVATED MACROPHAGES: ROLES IN HOMEOSTASIS AND DISEASE (2013, positive): “Arg1 is also induced by IL-4/IL-13 in macrophages and functions to counterbalance inflammatory signals that generate inducible nitric oxide synthase (iNOS), which also utilizes L-arginine to produce nitric oxide and L-citrulline (38).”
MyD88-dependent expansion of an immature GR-1+CD11b+ population induces T cell suppression and Th2 polarization in sepsis (2007, background): “Immature myeloid cells are capable of infl ammatory mediator production Because immature myeloid cells obtained from tumor-bearing hosts are known to be immunomodulatory (8, 9), we next examined whether cells obtained from septic mice could produce infl ammatory mediators, including IL-10, a cytokin”
Cancer despite immunosurveillance: immunoselection and immunosubversion (2006, background): “For example, some tumours (or tumour-associated myeloid cells) overproduce nitric oxide and have increased arginase-1 activity, both of which can inhibit T-cell functio”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “They suppress CD4 and CD8 T cells by their uptake of arginine and high intracellular level of arginase that depletes their surroundings of arginine, an essential amino acid for T cell activation (42, 45, 74).”