Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis.

By L. Baumgard, B. Corl, D. A. Dwyer, A. Saebo, D. Bauman. American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2000

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The composition of bovine milk lipids: January 1995 to December 2000. (2002, background): “Baumgard et al. (2000) confirmed with abomasal infusions that this isomer is responsible for the inhibition of MF synthesis.”
Nutritional regulation of milk fat synthesis. (2003, background): “(26) were the first to directly examine this by utilizing postruminal infusions of pure isomers of CLA.”
Diet, rumen biohydrogenation and nutritional quality of cow and goat milk fat (2007, background): “An inhibitory effect of t10c12-CLA onmilk fat synthesis andmammary lipogenic gene expression was demonstrated by duodenal infusion in dairy cows [74].”
Biosynthesis of Conjugated Linoleic Acid (CLA): A Review (2004, background): “The CLA concentration in liver and carcass content of these intermediates in the milk fat of lactating of the pups suckling these mothers was also higher. cows, and is implicated in reduced milk fat content Greater concentrations of CLA in mammary tissue and (Baumgard et al., 2001).”
Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids (2000, background): “Inhibition of FA synthesis and desaturation have been suggested in the ruminant mammary gland [14, 40].”