Excitatory actions of gaba during development: the nature of the nurture

By Yehezkel Ben-Ari. Nature Reviews Neuroscience, 2002

2,450 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Plant Science

View Paper: https://www.semanticscholar.org/paper/a73d55462959b537df1bea8282a162ce873f2ff7

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Citations in the corpus

Spontaneous network activity and synaptic development (2013, background): “In other circuits, the inhibitory switch of GABA- and glycinergic transmission contributes to the end of patterned spontaneous activity (Ben-Ari 2002; Owens and Kriegstein 2002).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “Survival and integration of newborn neurons are the main rate-limiting steps to the level of hippocampal neurogenesis (Kempermann et al., 2006).”
Synaptic integration and plasticity of new neurons in the adult hippocampus (2008, background): “GABAARs are chloride (Cl−) permeable channels and the polarity of GABA action depends on the Cl− gradient across the membrane, which in turn is determined by the developmentally regulated expression of C1− transporters (Owens et al. 1996; Ben-Ari, 2002; Tozuka et al. 2005; Ge et al. 2006).”
Is there more to gaba than synaptic inhibition? (2002, background): “GABA A -receptor-mediated membrane depolarization has been observed in developing cells from many brain regions, indicating a general role for GABA-mediated depolarization during developmen”
Excitatory GABA Action Is Essential for Morphological Maturation of Cortical Neurons In Vivo (2007, background): “However, GABA produces excitatory actions in the embryonic and neonatal brain (Ben-Ari, 2002).”
Editing modifies the GABAA receptor subunit α3 (2007, background): “However, until post-natal day (P) 8–12, GABA mediates the depolarization rather than hyperpolarization through the GABAA receptors (Ben-Ari 2002).”
Model of autism: increased ratio of excitation/inhibition in key neural systems (2003, background): “It should be noted that during development the GABAergic cortical cells are excitatory (Ben-Ari 2002).”
A Developmental Shift from Positive to Negative Connectivity in Human Amygdala-Prefrontal Circuitry (2013, methodology): “Although the present methodology does not allow for inferences about the direction of influence between the amygdala and mPFC, examination at the cellular level has identified developmental switching in the valence of connectivity across several modalities (Ganguly et al., 2001; Ben-Ari, 2002; Gille”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “, as is the case in early developing hippocampal cell”
Excitotoxicity: bridge to various triggers in neurodegenerative disorders. (2013, background): “Pharmacological, genetic and molecular investigations indicate that GABAergic neurons and GABAergic signaling are particularly important for brain development (Ben-Ari, 2002; Hensch et al., 2004).”
International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update (2008, background): “The situation occurs in nature and is especially relevant in early development (Ben-Ari, 2002).”
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, background): “At early developmental stages, activation of GABAA receptors leads to depolarization of adult-born GCs and to calcium influx, which activates a network of transcription factors that promote the growth of dendrites and spines (Ben-Ari, 2002; Owens and Kriegstein, 2002).”
Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo‐ocular learning (2012, neutral): “A depolarizing GABA response during early development is thought to be important for neuronal development (Ben-Ari, 2002).”
Becoming a new neuron in the adult olfactory bulb (2003, background): “Early onset of GABAergic synapses on newborn neurons In many immature brain regions, the primary inhibitory transmitter in the mature brain, GABA, first provides excitatory drive in the embryonic or neonatal brai”