Model of autism: increased ratio of excitation/inhibition in key neural systems

By John L. Rubenstein, Michael M. Merzenich. Genes, Brain and Behavior, 2003

2,693 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/9f5345227c4b7ede6457800f088644a0bae127d3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. R. Malenka
2. A. Citri
3. K. Tye
4. Xiao-Jing Wang
5. Y. Dan
6. Janet F. Werker
7. Karl Deisseroth
8. Takao K. Hensch

In Cognitive Neuroscience

1. R. Malenka
2. Xiao-Jing Wang
3. A. Citri
4. Y. Dan
5. K. Tye
6. Justin Riddle
7. Janet F. Werker
8. Ryan A. Stevenson

In Genetics

1. Benjamin M. Neale
2. Mark J. Daly
3. L. Weiss
4. J. Kosmicki
5. C. Betancur
6. Silvia De Rubeis
7. Xiao-Jing Wang
8. Kaitlin E. Samocha

Citations in the corpus

• Synaptic Plasticity: Multiple Forms, Functions, and Mechanisms (2008, background): “Thus, as predicted by theoretical considerations (Bienenstock et al, 1982; Stent, 1973), LTP and LTD mechanisms appear to be critically involved in early neural circuit development and it is not difficult to imagine how disruption in these mechanisms might contribute to a host of neurodevelopemental”
• Neurophysiological and Computational Principles of Cortical Rhythms in Cognition (2010, background): “erogeneous subtypes of autism (215, 825) could give rise”
• Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice (2019, neutral): “Some forms of ASD are thought to result from an imbalance between excitation and inhibition (E-I) in synaptic transmission and cortical circuitry (Lee et al., 2017; Nelson and Valakh, 2015; Rubenstein and Merzenich, 2003), although a recent report suggests E-I imbalance is not causative in some mous”
• Removing brakes on adult brain plasticity: from molecular to behavioral interventions (2010, positive): “Consistent with the theme developed here (Morishita and Hensch, 2008), one purported mechanism of action of these drugs may be to restore a more normal E/I balance (which is commonly impaired in such disorders) (Rubenstein and Merzenich, 2003; Polleux and Lauder, 2004; Gogolla et al., 2009).”
• Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism (2019, positive): “Placing these results in the context of multiple non-exclusive hypotheses around the origins of ASD, it is intriguing to speculate that the NC ASD genes provide compelling support for excitatory-inhibitory imbalance in ASD (Rubenstein and Merzenich, 2003) through direct effects on neurotransmission.”
• Vision in autism spectrum disorders. (2009, background): “Other studies that have suggested that neural noise is involved in ASD include: Rubenstein and Merzenich (2003), Belmonte and Yugelun-Todd (2003), Dakin and Frith (2005), Thornton (2006), Sanchez-Marin and Padina-Marilla (2008), Alcantara (2008), Lugo, Doti, and Faubert (2008) and Franklin et al.…”