Is there more to gaba than synaptic inhibition?

By D. Owens, A. Kriegstein. Nature Reviews Neuroscience, 2002

1,191 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Plant Science

View Paper: https://www.semanticscholar.org/paper/54bd31ce659216132bfa7e9e1eb5fd6df78ff5f5

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer’s Disease (2009, background): “At early developmental stages, activation of GABAA receptors leads to depolarization of adult-born GCs and to calcium influx, which activates a network of transcription factors that promote the growth of dendrites and spines (Ben-Ari, 2002; Owens and Kriegstein, 2002).”
GABA-CREB signalling regulates maturation and survival of newly generated neurons in the adult hippocampus (2009, background): “K -Cl cotransporter NKCC1 (BenAri, 2002; Owens and Kriegstein, 2002).”
Delayed Development of Adult-Generated Granule Cells in Dentate Gyrus (2006, background): “Consistent with a trophic role of GABA during development (Owens and Kriegstein, 2002), depolarizing GABAergic responses in neonates contributed to calcium signals in both unlabeled granule cells as well as labeled newborn granule cells.”
Origins of Cortical Interneuron Subtypes (2004, background): “In addition, they appear to regulate neuronal proliferation and migration later in corticogenesis (Owens and Kriegstein, 2002), as well as the postnatal development of cortical circuitry (Huang et al.”
Excitatory actions of gaba during development: the nature of the nurture (2002, background): “GABA has also been shown to positively stimulate several essential developmental functions, including neuronal migration, cell division and neuritic growt”
GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knock-in Mice (2009, background): “Thus, the increased NSC proliferation in apoE4-KI mice likely reflects impaired GABA signaling (Liu et al., 2005; Owens and Kriegstein, 2002; Tozuka et al., 2005).”
Neurosteroids: endogenous regulators of the GABAA receptor (2005, background): “In the mature brain, GABA functions mainly as an inhibitory neurotransmitter, but it is also an important trophic factor that influences various processes, particularly in the developing CNS, such as neuronal proliferation, differentiation, migration and synapse establismen”
NKCC1 transporter facilitates seizures in the developing brain (2005, background): “But in neonates, activation of Cl − -permeable GABA A -Rs excites many neuron”
Becoming a new neuron in the adult olfactory bulb (2003, background): “Early onset of GABAergic synapses on newborn neurons In many immature brain regions, the primary inhibitory transmitter in the mature brain, GABA, first provides excitatory drive in the embryonic or neonatal brai”