Raising cytosolic Cl− in cerebellar granule cells affects their excitability and vestibulo‐ocular learning

By Patricia Seja, M. Schonewille, G. Spitzmaul, Aleksandra Badura, Ilse Klein, Y. Rudhard, W. Wisden, C. Hübner, C. D. De Zeeuw, T. Jentsch. 2012

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Re-evaluating circuit mechanisms underlying pattern separation (2019, positive): “Raising the intrinsic excitability of cerebellar granule cells has been shown to impair the consolidation of learning (Seja et al., 2012), consistent with the idea that thresholding nonlinearities play an important role in pattern separation and associative learning.”
Silencing the majority of cerebellar granule cells uncovers their essential role in motor learning and consolidation. (2013, background): “…despite a lower number of GCs, whereas the level of learning and stability of learned responses, i.e., consolidation, should be affected as a consequence of a reduced capacity for effective plasticity inside the granular layer (Andreescu et al., 2011; Schweighofer et al., 2001; Seja et al., 2012).”
Network Structure within the Cerebellar Input Layer Enables Lossless Sparse Encoding (2014, methodology): “Lowering GC spike threshold by selectively deleting the KCC2 chloride transporter in GCs, which our results would suggest reduces the sparseness of encoding and thus pattern separation, impairs learning consolidation (Seja et al., 2012).”