Genetics of Alzheimer's Disease

By Perry G. Ridge, Mark T. W. Ebbert, John S. K. Kauwe. BioMed Research International, 2013

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Alzheimer's disease is the most common form of dementia and is the only top 10 cause of death in the United States that lacks disease-altering treatments. It is a complex disorder with environmental and genetic components. There are two major types of Alzheimer's disease, early onset and the more common late onset. The genetics of early-onset Alzheimer's disease are largely understood with variants in three different genes leading to disease. In contrast, while several common alleles associated with late-onset Alzheimer's disease, including APOE, have been identified using association studies, the genetics of late-onset Alzheimer's disease are not fully understood. Here we review the known genetics of early- and late-onset Alzheimer's disease.

Subfields: Molecular Biology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/9b2e37bd70678219fbf3b25cb593f895d2faffe8

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Citations in the corpus

Preclinical Alzheimer’s disease: Definition, natural history, and diagnostic criteria (2016, background): “This implies both that the same phenotype can be generated or altered by a number of different genetic loci and alleles and that mutations or polymorphisms at different positions in the same gene result in the same clinical syndrome [17].”
2016 Alzheimer's disease facts and figures (2016, positive): “These recently identified genes are believed to have a limited effect on the overall prevalence of Alzheimer’s because they are rare or only slightly increase risk [45].”
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques (2016, background): “Recent genome-wide association studies have identified rare variants of genes that encode immune receptors as risk factors (Guerreiro and Hardy, 2014; Karch and Goate, 2015).”
Alzheimer’s disease: experimental models and reality (2017, background): “sAD afflicts >95% of patients with AD and is related to both genetic and environmental factors [7, 52, 74, 76] (see Fig.”