Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

By G. Bu. Nature Reviews Neuroscience, 2009

1,108 citations recorded by the source corpus.

Subfields: Pharmacology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/18c7b8f91393d70d4f393a18eb6c3c28b25c5c7d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Pharmacology

1. J. Herz
2. D. Holtzman
3. Martin Citron
4. Fred H. Gage
5. G. Bu
6. Ernest Arenas
7. Nibaldo C. Inestrosa
8. Yangling Mu

In Physiology

1. D. Holtzman
2. Martin Citron
3. J. Herz
4. G. Bu
5. John C. Morris
6. John Hardy
7. Fred H. Gage
8. Yangling Mu

In Surgery

1. D. Holtzman
2. J. Herz
3. Martin Citron
4. Fred H. Gage
5. Ernest Arenas
6. Nibaldo C. Inestrosa
7. Yangling Mu

Citations in the corpus

• Mechanisms Underlying Inflammation in Neurodegeneration (2010, neutral): “With respect to the roles of apoE and its receptors in the regulation of APP processing, LRP1 has been suggested to directly bind to Ab or Ab/apoE complexes, mediating their uptake by glial cells, which is neuroprotective (Marzolo and Bu, 2009).”
• Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease. (2012, positive): “2010), as well as learning and memory (reviewed in Herz and Beffert 2000; Herz and Chen 2006; Bu 2009; Herz 2009).”
• Emerging roles of Wnts in the adult nervous system (2010, background): “The apolipoprotein E e4 allele, which is associated with an increased risk of developing A”
• Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease (2010, background): “This occurs in astrocytes and microglia, the cholesterol then being loaded into APOE lipoprotein particles and transported to the main cholesterol users, neurons and oligodendrocytes [34].”
• Alzheimer's disease: strategies for disease modification (2010, background): “The fact that e4 is also a risk factor for a number of other conditions (reviewed in Ref”
• Role of neuroinflammation in neurodegeneration development (2023, background): “RAGE is also reported to play an important role in the uptake of Aβ by microglia.(333) The binding of Aβ to RAGE mediates Aβ transport from the cellular surface to mitochondria in microglia.”
• Adult hippocampal neurogenesis and its role in Alzheimer's disease (2011, background): “While aging is the greatest environmental risk factor of the sporadic form, the presence of the ε 4 allele in apolipoprotein E (ApoE4) represents the most important genetic risk factor [29].”