ATP drives lamina propria TH17 cell differentiation

By K. Atarashi, J. Nishimura, T. Shima, Y. Umesaki, Masahiro Yamamoto, M. Onoue, H. Yagita, N. Ishii, R. Evans, K. Honda and 1 more. Nature, 2008

1,096 citations recorded by the source corpus.

Subfields: Genetics, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/a3f65d2de2ab2144685eeae6cf57c78ee99a0857

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. B. B. Finlay
2. Dan R. Littman
3. I. Ivanov
4. N. Manel
5. S. Mazmanian
6. June L. Round
7. Rosa de Frutos
8. D. Rifkin

In Immunology

1. Dan R. Littman
2. A. Jetten
3. K. Honda
4. C. Dong
5. R. Medzhitov
6. S. Ghosh
7. Steffen Jung
8. Shizuo Akira

In Physiology

1. F. Quintana
2. S. Ghosh
3. B. B. Finlay
4. Dan R. Littman
5. Eric G. Pamer
6. Steffen Jung
7. A. Giuliani
8. A. Sarti

Citations in the corpus

• Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions (2009, background): “Numerous publications have examined the antigen-presenting capacity of LP macrophages and DCs and the quality of the ensuing immune response using in vitro co-culture assays (Laouar et al., 2005; Uematsu et al., 2006, 2008; Denning et al., 2007; Atarashi et al., 2008).”
• Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. (2008, background): “Recent data has demonstrated that bacterially produced ATP can directly augment Th17 differentiation (Atarashi et al., 2008), whereas commensal flora may inhibit this pathway via IL-25 (Zaph et al.”
• Specific microbiota direct the differentiation of Th17 cells in the mucosa of the small intestine (2008, positive): “Another study recently reported that lack of avb8, one of the major TGF-b activators, on DCs led to loss of Foxp3+ Tregs in the lamina propria (Travis et al., 2007).”
• The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition (2014, background): “Indeed, emerging evidence suggests that the immune system can sense microbial products in addition to pathogen-associated molecular patterns and that recognition of these small molecules can influence the host immune response (10).”
• Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells (2015, neutral): “…Th17 differentiation (Yang et al., 2014), and microbiota-mediated Th17 cell development occurs independently of major innate immune receptors (Atarashi et al., 2008; Ivanov et al., 2009), SFB colonization must elicit unique signaling pathways in the intestine to generate a Th17-conducive…”
• Homeostatic immunity and the microbiota (2017, neutral): “In germ-free mice, or mice treated with broadspectrum antibiotics, Th17 cell frequencies are severely reduced within the gut-associated lymphoid tissue (GALT) or within the skin compartment (Atarashi et al., 2008; Hall et al., 2008; Ivanov et al., 2008; Naik et al., 2012).”
• The IL-1 family: regulators of immunity (2010, background): “T H 17 cells are particularly prevalent in the gut, which may be due to enhanced inflammasome activation and IL-1 secretion in response to commensal-derived ATP (ATP is a strong activator of the inflammasome through the P2X7 purinergic receptor”
• The P2X7 Receptor in Infection and Inflammation (2017, positive): “In the mouse, extracellular ATP and P2X7R have been shown to be necessary for Th17 cell differentiation (Atarashi et al., 2008; Fan et al., 2016), a process enhanced by glycolytic metabolism and thus possibly promoted by a lower”
• Intestinal lamina propria dendritic cell subsets have different origin and functions. (2009, background): “The latter is also supported by a CD70 CD11b lpDC subset driven by microflora-derived ATP (Atarashi et al., 2008).”
• Regulation of Inflammation by Short Chain Fatty Acids (2011, background): “This nucleotide induces the differentiation of an important subset of CD4+ lymphocytes, the Th17 cells [8].”
• Critical regulation of early Th17 cell differentiation by IL-1 signaling (2009, background): “inflammasome activator, drives Th17 cell differentiation in the gut (Atarashi et al., 2008), suggesting a role of IL-1 for the generation of Th17 cells in the gut.”
• The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. (2009, result): “Consistent with most recent reports (Atarashi et al., 2008; Ivanov et al., 2008; Niess et al., 2008; Zaph et al., 2008), we confirm that the gut microbiota is a potent stimulus of Th17 cell differentiation.”
• The role of gut microbiota in immune homeostasis and autoimmunity (2012, background): “Moreover, microbe-derived ATP has recently been shown to stimulate a subset of DCs that express CD70 and CX3CR1 on their surface, which then induce the differentiation of Th17 cells.(24) Intestinal macrophages represent the largest population of tissue macrophages in the body.”