The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

By Pamela V. Chang, L. Hao, S. Offermanns, R. Medzhitov. Proceedings of the National Academy of Sciences of the United States of America, 2014

1,948 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/a33b9bd0fc063b18918174681cf0e2a3b2d28c85

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. Y. Belkaid
2. O. Harrison

In Molecular Biology

1. F. Leroy
2. L. De Vuyst
3. S. Ghosh
4. Galeb Abu-Ali
5. Jason Lloyd-Price
6. T. Preston
7. F. Powrie
8. Lan Lin

In Physiology

1. Galeb Abu-Ali
2. S. Ghosh
3. Curtis Huttenhower
4. C. Mackay
5. Y. Belkaid
6. O. Harrison
7. T. Postler

Citations in the corpus

• Fat, Fiber and Cancer Risk in African Americans and Rural Africans (2015, neutral): “Interestingly, the microbial metabolite, butyrate, was shown recently to reduce the responsiveness of lamina propria macrophages to commensal bacteria 45 , suggesting that the dietary change in Americans may have resulted in a decrease in both macrophage numbers and their activity.”
• Human gut microbiota/microbiome in health and diseases: a review (2020, neutral): “Faecalibacterium prausnitzii Modulate intestinal macrophage function (Chang et al. 2014)”
• The Balance of Th17 versus Treg Cells in Autoimmunity (2018, background): “Th17 cells are thought to be the main driver of pathogenesis by initiating inflammation via activation of many cell types within the inflamed joint, including macrophages, DCs, and synoviocytes.”
• Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism (2020, background): “In other studies, butyrate and propionate treatment can inhibit the secretion of TNFα and the activity of NF-κB and up-regulate the expression of anti-inflammatory factors IL-10 in LPS-activated mononuclear cells and neutrophils by HDAC inhibition [84,100,101].”
• Understanding the Holobiont: How microbial metabolites affect human health and shape the immune system (2017, background): “Arpaia et al., 2013; Brown et al., 2003; Chang et al., 2014; Donohoe et al., 2012; Kalina et al., 2002; Kim et al., 2016; Le Poul et al., 2003; Macia et al., 2015; Maslowski et al., 2009; Millard et al., 2002; Nilsson et al., 2003; Singh et al., 2010; Smith et al., 2013; Thangaraju et al., 2009a,…”
• From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. (2016, neutral): “propria macrophages (Chang et al., 2014) and differentiation of dendritic cells from bone marrow stem cells (Singh et al.”
• Butyrate: A Double-Edged Sword for Health? (2018, background): “MCTs are also involved in butyrate transport on the apical membrane of colonocytes (30).”