The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses.

By V. Gaboriau-Routhiau, S. Rakotobe, Emelyne Lécuyer, I. Mulder, Annaïg Lan, C. Bridonneau, V. Rochet, A. Pisi, Marianne De Paepe, G. Brandi and 4 more. Immunity, 2009

1,448 citations recorded by the source corpus.

Subfields: Immunology, Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/048a8f552035efab1a8614d9447af7e24633121e

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Citations in the corpus

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells (2015, neutral): “Among commensals, segmented filamentous bacteria (SFB) are one of the most potent inducers of Th17 cells, and monocolonization of mice with SFB causes abundant accumulation of Th17 cells in the small intestinal (SI) LP (Gaboriau-Routhiau et al., 2009; Ivanov et al., 2009).”
Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis (2011, background): “and, in part, by monoassociation of mice with specific bacteri”
The role of gut microbiota in immune homeostasis and autoimmunity (2012, background): “In contrast, segmented filamentous bacteria (SFB) were found to be potent inducers of LP Th17 cells.(17,40) As IL-17 is a crucial pro-inflammatory cytokine, it will be of interest to see if there are other intestinal bacteria that can also induce Th17 cells.”
Role of the Microbiota in Immunity and inflammation (2014, background): “SFB has a dominant effect on the mucosal immune system by promoting the accumulation of both Th17 and Th1 cells in the small intestine and driving the production of IgA (Gaboriau-Routhiau et al., 2009; Ivanov et al., 2009; Umesaki et al., 1999).”
Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis (2010, background): “For example, adherent cecal segmented filamentous bacteria have recently been shown to play a central role in the development of IL-17producing CD4+ T helper cells in mice (Ivanov et al., 2009; Gaboriau-Routhiau et al., 2009).”
Intestinal homeostasis and its breakdown in inflammatory bowel disease (2011, background): “The microbiota has an important role in the preferential localization of T H 17 cells in the gut, as the colonization of germ-free mice with segmented filamentous bacteria led to the marked accumulation of T H 17 cells in the intestinal lamina propri”
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease (2017, background): “Enhanced SFB adhesion on the epithelial induces the expression and release of serum amyloid A (SAA) from intestinal epithelial cells (IECs), and SAA potentiates the production of IL- 1β and IL- 23 in CX3CR1+ phagocytes, two cytokines that synergistically promote the production of IL- 22 in ILC3.”
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota (2010, background): “Germ-free mice display very low numbers of Th17 cells within the lamina propria that is restored upon colonization with a complex microbial consortium (9-11) or even specific bacterial species (12, 13).”
Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa (2011, background): “For instance, a disproportionate outgrowth of bacteria of the genus Clostridium promotes T cell-mediated pro-inflammatory immune response”
Homeostatic immunity and the microbiota (2017, neutral): “…the terminal ileum of mice and has a dominant effect on the mucosal immune system by promoting the accumulation of both Th17 and Th1 cells in the small intestine and driving the production of IgA (Gaboriau-Routhiau et al., 2009; Ivanov et al., 2009; Talham et al., 1999; Umesaki et al., 1999).”
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease (2012, background): “intestinal epithelium [35], have been shown to induce Th17 responses [36] and increase the number of Treg cells in both the small intestine and colon [37].”