Structure and function of dendritic spines.

By E. Nimchinsky, Bernardo L. Sabatini, Karel Svoboda. Annual Review of Physiology, 2002

1,233 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a33cd3355c1cae6f9d20ff9fc2b812ae2919a766

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Citations in the corpus

Distinct Mammalian Precursors Are Committed to Generate Neurons with Defined Dendritic Projection Patterns (2007, background): “= 10 GCs for each time point and condition). Dendritic spines are the major sites of excitatory synaptic transmission in the mammalian brain [”
Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. (2006, background): “…it is worth noting that changes in dendritic spine morphology and number are associated with a number of neurological disorders (Fiala et al., 2002; Nimchinsky et al., 2002) A decrease in axospinous synaptic input to the medial PFC by 33% may have a significant impact on the functional properties…”
Spine Plasticity in the Motor Cortex (2010, background): “Not only are spines heterogeneous in shape, their density also varies among different types of neurons and in different developmental stages [8].”
Experience-dependent structural synaptic plasticity in the mammalian brain (2009, background): “Spines are tiny protrusions that emanate from the dendritic shaf”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “It has been suggested that the structural changes underlying plasticity exist at the levels of dendritic spines, dendrites, and axons (28, 287, 297, 383, 408).”
Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus (2006, background): “Spines are extremely diversified (Jones and Powell, 1969; Peters and KaisermanAbramof, 1970), and they have been categorized into four different types on the basis of their morphology: mushroom, thin, stubby, and filopodia (Nimchinsky et al., 2002; Sala, 2002).”
Structural plasticity associated with exposure to drugs of abuse. (2004, neutral): “…spines may modify synaptic efficacy by altering the chemical microenvironment or the electrotonic properties of the synapse (Horner, 1993; Rusakov et al., 1996; Shepherd, 1996; Nimchinsky et al., 2002; Tsay and Yuste, 2004), or by altering fast synaptic neurotransmission (Kasai et al., 2003).”
Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. (2006, background): “…tested the effect of mutating MeCP2 at its site of activity-dependent phosphorylation (S421) on the development of dendritic spines, the major sites of excitatory synaptic transmission onto neurons that are thought to be morphological correlates of synaptic contacts (Nimchinsky et al., 2002).”
Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo (2006, background): “[1,2], tiny membrane protrusions that contain the postsynap-”
Long-term plasticity of intrinsic excitability: learning rules and mechanisms. (2003, neutral): “In fact, the use of patch-clamp recordings and/or imaging techniques have identified voltage-gated Ca 2+ , Na + , and K + channels in dendritic spines (for review, see Nimchinsky et al. 2002) and dendritic shafts of hippocampal and neocortical pyramidal neurons (for a recent review, see Reyes 2002).”
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex (2002, background): “Spines are tiny dendritic protrusions that receive the vast majority of excitatory synapse”
Mismatch negativity in schizophrenia: a meta-analysis. (2005, background): “Interestingly, dendritic spines are a primary location of NMDA receptors (Nimchinsky et al., 2002).”
Structural Plasticity and Hippocampal Function (2010, background): “The high concentration of adrenal steroid receptors in the hippocampus (reviewed in de Kloet et al. 1998) and the hippocampal projections to the hypothalamus (reviewed in Ulrich-Lai & Herman 2009) provide an indirect link between the hippocampus and regulation of the stress response.”
Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images (2008, background): “From a biophysical viewpoint, these effects give rise to increased synaptic currents and reduced time constants for calcium compartmentalization in larger spine heads (see refs [5,20] for review), modulating postsynaptic mechanisms that determine functions such as learning and memory [21–24].”
Molecular mechanisms of dendritic spine morphogenesis. (2006, background): “Although small in size (up to a few microns in length), spines appear to contain all the essential molecules and organelles involved in postsynaptic signaling and plasticity [1,2].”
Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits (2006, background): “However, are structural changes really only a slow mechanism? Novel in vivo imaging techniques used in combination with genetic labeling allow the determination of whether rapid changes in dendritic spine structure (Yuste and Bonhoeffer, 2001; Nimchinsky et al., 2002; Hayashi and Majewska, 2005) acc”
Dendritic excitability and synaptic plasticity. (2008, neutral): “For example, spines are the target of the majority of excitatory synapses (86, 557), but why is this the case?”