Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex.

By J. Radley, Anne B. Rocher, Melinda M. Miller, W. Janssen, Conor Liston, Patrick R. Hof, Bruce S. McEwen, John H. Morrison. Cerebral Cortex, 2006

815 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cellular and Molecular Neuroscience, Physiology

View Paper: https://www.semanticscholar.org/paper/0249815c9fdd611158c1acf8759656ca5761b4d2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. Bruce S. McEwen
2. John H. Morrison
3. B. Casey
4. Conor Liston
5. Michael T. Treadway
6. David H. Zald
7. S. Salim
8. J. Wingfield

In Cellular and Molecular Neuroscience

1. Bruce S. McEwen
2. Melinda M. Miller
3. John H. Morrison
4. B. Casey
5. Conor Liston
6. David H. Zald
7. Patrick R. Hof
8. J. Radley

In Physiology

1. John H. Morrison
2. Bruce S. McEwen
3. J. Wingfield
4. Carol Worthman

Citations in the corpus

• Stress-Induced Alterations in Prefrontal Cortical Dendritic Morphology Predict Selective Impairments in Perceptual Attentional Set-Shifting (2006, methodology): “Our results confirm that chronic stress reduces apical dendritic material by ϳ20%, which, in combination with a 16% reduction in spine density (Radley et al., 2006), may lead to a 33% reduction in axospinous input to layer II/III apical dendrites in the ACg.”
• Psychosocial stress reversibly disrupts prefrontal processing and attentional control (2009, background): “Stress effects on PFC function may therefore be attributable to both acute changes in monoaminergic tone and longer-term structural changes in dendritic arborization and spine density that perturb functional connectivity (12, 15).”
• Central effects of stress hormones in health and disease: Understanding the protective and damaging effects of stress and stress mediators. (2008, background): “…shortening in medial prefrontal cortex (Sousa et al., 2000; Wellman, 2001; Vyas et al., 2002; Kreibich and Blendy, 2004; Cook andWellman, 2004; Radley et al., 2004, 2006; Brown et al., 2005) but produces dendritic growth in neurons in amygdala (Vyas et al., 2002), as well as in orbitofrontal…”
• Oxidative Stress and the Central Nervous System (2017, neutral): “And, oxidative stress–initiated neuroendocrine alterations within the amygdala, including amygdalar hyperactivity and dendritic shrinking (Wellman, 2001; Vyas et al., 2002; Kreibich and Blendy 2004; Brown et al., 2005; Radley et al., 2006; Wood et al., 2010), can further potentiate synaptic disturba”
• Stress and Memory: Behavioral Effects and Neurobiological Mechanisms (2007, neutral): “[165]) in layers II/III.”
• Stress signalling pathways that impair prefrontal cortex structure and function (2009, neutral): “The layer II/III neurons that form PFC networks lose dendritic material — that is, dendrite length, branching and spine density are reduced by chronic stres”
• Reconsidering Anhedonia in Depression: Lessons from Translational Neuroscience (2010, background): “Stress has been shown to increase glucocorticoid signaling (Holsboer, 2000), precipitate neuronal degeneration in the hippocampus (Sapolsky, 2000) and medial prefrontal cortex (McEwen, 2005; Radley et al., 2006), decrease the availability of brainderived neurotrophic factor (BDNF) (Duman, 2009), and”