Long-term plasticity of intrinsic excitability: learning rules and mechanisms.

By Gaël Daoudal, D. Debanne. 2003

549 citations recorded by the source corpus.

Spatio-temporal configurations of distributed activity in the brain is thought to contribute to the coding of neuronal information and synaptic contacts between nerve cells could play a central role in the formation of privileged pathways of activity. Synaptic plasticity is not the exclusive mode of regulation of information processing in the brain, and persistent regulations of ionic conductances in some specialized neuronal areas such as the dendrites, the cell body, and the axon could also modulate, in the long-term, the propagation of neuronal information. Persistent changes in intrinsic excitability have been reported in several brain areas in which activity is elevated during a classical conditioning. The role of synaptic activity seems to be a determinant in the induction, but the learning rules and the underlying mechanisms remain to be defined. We discuss here the role of synaptic activity in the induction of intrinsic plasticity in cortical, hippocampal, and cerebellar neurons. Activation of glutamate receptors initiates a long-term modification in neuronal excitability that may represent a parallel, synergistic substrate for learning and memory. Similar to synaptic plasticity, long-lasting intrinsic plasticity appears to be bidirectional and to express a certain level of input or cell specificity. These nonsynaptic forms of plasticity affect the signal propagation in the axon, the dendrites, and the soma. They not only share common learning rules and induction pathways with the better-known synaptic plasticity such as NMDA receptor dependent LTP and LTD, but also contribute in synergy with these synaptic changes to the formation of a coherent engram.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

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Citations in the corpus

Non-commercial Research and Educational Use including without Limitation Use in Instruction at Your Institution, Sending It to Specific Colleagues That You Know, and Providing a Copy to Your Institution's Administrator. All Other Uses, Reproduction and Distribution, including without Limitation Comm (2005, unknown): “A detailed description of the GA used in this investigation can be found in [18–20].”
The role of phase synchronization in memory processes (2011, background): “To facilitate neural communication, the temporal precision of these coincident synaptic inputs has to be in the millisecond rang”
New circuits for old memories: the role of the neocortex in consolidation. (2004, unknown): “Neuron 41, 781–793.a role in consolidation (Daoudal and Debanne, 2003; Daoudal, G., and Debanne, D. (2003).”
On Having No Head: Cognition throughout Biological Systems (2016, background): “The main principles by which neural networks store and process information – plasticity, excitability, and experiencedependent change (Daoudal and Debanne, 2003) are readily applicable to numerous cell types.”
Neuronal homeostasis: time for a change? (2011, background): “…properties of cells – properties that dictate how a cell integrates and responds to electrical signals – are themselves capable of being modified in response to particular patterns of activity in ways that facilitate learning and development (Daoudal & Debanne, 2003; Disterhoft & Oh, 2006).”
Concepts of neural nitric oxide-mediated transmission (2008, background): “This review has attempted to encapsulate the substantial progress made in recent years towards understanding the cellular and molecular mechanisms through which NO acts in the mammalian CNS, mechanisms that must ultimately explain the multifarious behavioural effects of NO evident at the…”
Reinforcement Learning Through Modulation of Spike-Timing-Dependent Synaptic Plasticity (2007, background): “This is consistent with experimental results that showed that neural excitability increases after bursts (Aizenman & Linden, 2000; Cudmore & Turrigiano, 2004; Daoudal & Debanne, 2003).”
Memory Engram Cells Have Come of Age. (2015, unknown): “There have also been studies suggesting that a cell-wide alteration, such as augmented intrinsic excitability, may contribute to memory (Daoudal and Debanne, 2003).”
Burst timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons: A putative cellular substrate for reward learning (2009, unknown): “3 METAPLASTICITY The plasticity of NMDARs is of particular interest due to its dominant role in controlling the plasticity of AMPARs as well a variety of ion channels that have been shown to regulate intrinsic excitability (Campanac and Debanne, 2007; Daoudal and Debanne, 2003; Debanne et al., 2003;”
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement. (2011, background): “…2004, Desai et al. 1999, Nataraj et al. 2010); furthermore, as for synaptic homeostatic mechanisms, there appear to be a variety of intrinsic plasticity processes that operate over distinct spatial and temporal scales to modulate neuronal activity (Daoudal & Debanne 2003, Zhang & Linden 2003).”