Distinct Mammalian Precursors Are Committed to Generate Neurons with Defined Dendritic Projection Patterns

By W. Kelsch, Colleen P. Mosley, Chia-Wei Lin, C. Lois. PLoS Biology, 2007

93 citations recorded by the source corpus.

The mechanisms that regulate how dendrites target different neurons to establish connections with specific cell types remain largely unknown. In particular, the formation of cell-type–specific connectivity during postnatal neurogenesis could be either determined by the local environment of the mature neuronal circuit or by cell-autonomous properties of the immature neurons, already determined by their precursors. Using retroviral fate mapping, we studied the lamina-specific dendritic targeting of one neuronal type as defined by its morphology and intrinsic somatic electrical properties in neonatal and adult neurogenesis. Fate mapping revealed the existence of two separate populations of neuronal precursors that gave rise to the same neuronal type with two distinct patterns of dendritic targeting—innervating either a deep or superficial lamina, where they connect to different types of principal neurons. Furthermore, heterochronic and heterotopic transplantation demonstrated that these precursors were largely restricted to generate neurons with a predetermined pattern of dendritic targeting that was independent of the host environment. Our results demonstrate that, at least in the neonatal and adult mammalian brain, the pattern of dendritic targeting of a given neuron is a cell-autonomous property of their precursors.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4962d232948a74e2e4c1f2c06ba2e38ee76b51bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

In Developmental Neuroscience

In Molecular Biology

Citations in the corpus

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury. (2015, unknown): “These subtypes are believed to be derived from distinctly located sets of committed NSCs, and not from a pan-subtype multipotent NSC (Brill et al., 2009; Kelsch et al., 2007; Merkle et al., 2007; Young et al., 2007).”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, unknown): “lineage tracing in neonatal and adult mice revealed that specific subtypes of interneurons are made within specific adult VZ-SVZ locations (Figure 2)(Kelsch et al., 2007; Kohwi et al., 2007; Merkle et al., 2007; Ventura and Goldman, 2007; Young et al., 2007).”
Eyes Wide Open: A Critical Review of Sphere-Formation as an Assay For Stem Cells (2011, methodology): “Interestingly, the side population purification method, in which Hoechst exclusion is used to prospectively isolate stem cells (reviewed in Golebiewska et al., 2011), is not selective for neurosphere-forming cells (Kim and Morshead, 2003).”
A Dlx2- and Pax6-Dependent Transcriptional Code for Periglomerular Neuron Specification in the Adult Olfactory Bulb (2008, background): “These observations also bear relevance in regard to the diverse origin of PGN subtypes at distinct positions and the proposition that distinct stem cell pools are fate-restricted toward the generation of specific neuronal subtypes (Hack et al., 2005; Kelsch et al., 2007; Merkle et al., 2007).”