Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

By M. S. Rao, A. Shetty. European Journal of Neuroscience, 2004

693 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/a2afc6d5a60f802c32c366854f42f9851ad5b1fe

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. Fred H. Gage
2. D. Abrous
3. R. Duman
4. M. Koehl
5. M. Le Moal
6. H. Schmidt
7. Gerd Kempermann
8. Hongjun Song

In Genetics

1. M. Le Moal
2. E. Masliah
3. Fred H. Gage
4. C. A. Barnes
5. H. Schmidt
6. J. Siegel
7. D. Abrous
8. R. Duman

In Neurology

1. Fred H. Gage
2. D. Abrous
3. M. Koehl
4. M. Le Moal
5. R. Duman
6. Gerd Kempermann
7. Elodie Drapeau
8. M. Montaron

Citations in the corpus

• In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis (2013, background): “2011), it has been established that DCX immunolabelling of granule cells of the dentate gyrus is a good proxy for the presence of adult hippocampal neurogenesis (Rao and Shetty 2004; Couillard-Despres et al. 2005).”
• Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. (2007, neutral): “P, arrowhead) (Brown et al., 2003; Rao and Shetty, 2004; Rao et al., 2005).”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “In contrast, approximately 4000 cells, of which 3000 differentiate into neurons, are generated per day (B120 000 new cells per month) in the hippocampus of adult rodents (Rao and Shetty, 2004).”
• Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years (2010, background): “A central phase during this development is associated with the expression of doublecortin (DCX) [18,19,20].”
• Doublecortin expression levels in adult brain reflect neurogenesis (2005, background): “However, during this period, dendrite formation and branching occurs, leading to the suggestion that detection of DCX expression in the adult dentate gyrus could be used as a quantitative mean for the analysis of dendritic branching (Rao & Shetty, 2004).”
• Integration of New Neurons into Functional Neural Networks (2006, background): “…that new granule neurons integrate anatomically into the network by developing appropriate dendritic (Ambrogini et al., 2004; Fujioka et al., 2004; Rao and Shetty, 2004; Esposito et al., 2005; Rao et al., 2005; Ge et al., 2006; Overstreet-Wadiche et al., 2006a,b) and axonal (Hastings and Gould,…”
• Adult neurogenesis: from precursors to network and physiology. (2005, background): “In a more recent study, only 4,000 new cells, out of which 3,000 were found to be new neurons, were shown to be added daily in the DG of 4-mo-old rats (456); this discrepancy in the number of newborn cells is certainly linked to the difference in the age of the animals used in the studies, as the pr”
• Visualization and genetic manipulation of adult neurogenesis using transgenic mice (2011, background): “DCX reporter mice emerged following studies that implicated DCX as a reliable marker for neurogenesis (Brown et al., 2003; Rao & Shetty, 2004; Song et al., 2005).”
• Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “The dentate gyrus (DG) of the hippocampal formation is one of the few structures where adult neurogenesis occurs in mammals [4], and it has been estimated that several thousand new cells are generated daily [5,6].”
• Granule cell dispersion is not accompanied by enhanced neurogenesis in temporal lobe epilepsy patients. (2007, background): “DCX is an established marker for newly generated neurons in the subgranular zone of the adult rodent and human dentate gyrus (Brown et al., 2003; Rao and Shetty, 2004; CouillardDespres et al., 2005; Jin et al., 2004).”
• Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus (2005, methodology): “In order to obtain a supplementary index of neurogenesis, we also analysed the number of immature neurons in the DG by the means of DCX, a microtubule-associated phosphoprotein (Rao & Shetty, 2004).”
• Molecular mechanisms of neurodegeneration in Alzheimer's disease. (2010, methodology): “For later stages in the process, markers such as doublecortin (DCX) or b-III Tubulin are utilized to detect progeny in the early neuroblast phase (newly born neurons, often migratory) or immature new neurons, respectively [(62) Fig.”