Core transcriptional regulatory circuitry in human embryonic stem cells.

By Laurie A. Boyer, Tong Ihn Lee, Megan F. Cole, Sarah E. Johnstone, S. Levine, J. Zucker, M. Guenther, Roshan M. Kumar, Heather L. Murray, Richard G. Jenner and 4 more. Cell, 2005

4,688 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/a23d1ea9842301a8e13ccc702bb600b6c572c27a

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Citations in the corpus

Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells (2007, background): “This concept is supported by chromatin immunoprecipitation (ChIP) studies in both human and mouse ES cells, suggesting that Oct3/4 and Sox2 cooperatively activate or repress a set of genes (including Oct3/4 , Sox2 and Nanog ) through their Oct–Sox enhancers; this, in turn, results in their coope”
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. (2009, neutral): “The self-renewal and pluripotency properties are regulated by an array of protein-coding genes, such as transcription factors and chromatin remodeling enzymes, in a core regulatory circuitry (Boyer et al., 2005; Jaenisch and Young, 2008).”
A global map of p53 transcription-factor binding sites in the human genome. (2006, background): “Most applications are so far restricted to promoter microarrays containing CpG islands or flanking sequences around transcription start sites and specific chromosome arrays (Horak et al., 2002; Weinmann et al., 2002; Cawley et al., 2004; Boyer et al., 2005).”
Control of Embryonic Stem Cell State (2011, background): “The interconnected autoregulatory loop formed by Oct4, Sox2, and Nanog generates a bistable state for ESCs: residence in a positive-feedback-controlled gene expression program when the factors are expressed at appropriate levels, versus entrance into a differentiation program when any one of the mas”
Somatic cell reprogramming and transitions between pluripotent states: facts, hypotheses, unresolved issues (2010, neutral): “…from the highly interconnected DNA-binding properties of the pluripotency factors that form the regulatory circuitry and that allow the transduced transcription factors to reestablish the autoregulatory and feed-forward loops by activating the endogenous pluripotency genes (Boyer et al., 2005).”
Nanog Is the Gateway to the Pluripotent Ground State (2009, neutral): “Nanog is a highly divergent homeodomain-containing protein commonly accorded a central position in the transcriptional network of pluripotency (Boyer et al., 2005; Cole et al., 2008; Loh et al., 2006; Wang et al., 2006).”
Induction of pluripotent stem cells from adult human fibroblasts by defined factors. (2007, background): “The function of Oct3/4 and Sox2 as core transcription factors to determine pluripotency is well documented (Boyer et al., 2005; Loh et al., 2006; Wang et al., 2006).”
Quantitative and logic modelling of gene and molecular networks (2015, background): “BioModels (32) is an example of a database that provides a large collection of mathematical models of biological processes encoded in SBML.”
Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling (2011, positive): “Examination of binding data at individual genes such as that encoding Max (Figure 2A) revealed that Smad3 co-occupied sites with Oct4 as well as Sox2 and Nanog, which are key ESC transcription factors that occupy the genome together (Boyer et al., 2005; Chen et al., 2008; Marson et al., 2008).”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, background): “We demonstrate that the two key signaling pathways are integrated to the Oct4, Sox2, and Nanog circuitries through Smad1 and STAT3.”
Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts (2010, background): “We note, in passing, that positive feedback loops are used, for example, to maintain the undifferentiated state of embryonic stem cells and hematopoietic progenitor cells (52, 53).”