MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.

By N. Xu, T. Papagiannakopoulos, G. Pan, James A. Thomson, Kenneth S. Kosik. Cell, 2009

1,189 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/353d360eb1a3b035fb05a78a5ec20c7b339d9a5c

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In Cancer Research

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In Molecular Biology

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Citations in the corpus

• MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. (2009, background): “Forced expression of miR-145 in cultured SMCs has also been reported to increase the expression of smooth muscle differentiation markers, and, conversely, inhibition of miR-145 expression with an antisense oligonucleotide interferes with smooth muscle differentiation in vitro (Cordes et al. 2009; Xu”
• Posttranscriptional regulation of microRNA biogenesis in animals. (2010, background): “…appears to induce the dissociation of the Microprocessor complex from the pri-miRNAs or a conformational change of the Microprocessor with the consequence of reduced association prior to interaction with the pri-miRNAs, thereby blocking Drosha-mediated processing (Yamagata et al., 2009).”
• Risk factors in the development of stem cell therapy (2011, background): “They have highly similar growth characteristics, gene expression profiles, epigenetic modifications and developmental potential [16-18].”
• MicroRNA control of signal transduction (2010, background): “BMP signalling promotes the differentiation of human ES cells by inhibiting OCT4 and by sustaining the expression of miR-145, thus ensuring a firm inhibition of pluripotency gene”
• Non-coding RNAs as regulators of embryogenesis (2011, neutral): “For example, human miR-145 downregulates OCT4 , SOX2 and KLF4 upon differentiatio”
• Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster. (2009, result): “We did not observe defects during early embryogenesis, which is in contrast to the recently reported function of miR-145 as an inducer of lineagerestricted differentiation (28).”
• The Sox Family of Transcription Factors: Versatile Regulators of Stem and Progenitor Cell Fate (2013, neutral): “FoxD3 occupies the enhancer of the silent liver-specific Alb1 gene in ESCs, thereby keeping it poised for activation upon differentiation into liver cells, when FoxA1 replaces FoxD3 to activate transcription (Xu et al., 2009b).”
• MicroRNAs in development and disease. (2011, background): “Although the results of genomic ablation of miR-145/143 in mice would argue against its involvement in cell specification or fate, cell culture studies demonstrate that increased expression of miR-145 in human embryonic stem cells is both necessary and sufficient for inducing their differentiation i”