Autocrine TGF-β and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

By Y. Kojima, A. Acar, E. Eaton, K. Mellody, C. Scheel, I. Ben-Porath, T. Onder, Z. Wang, A. Richardson, R. Weinberg and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2010

833 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/9a66667fb26c2b175aae3ee2f4440fcc97f0549a

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In Genetics

1. M. Mareel
2. B. Hinz
3. R. Derynck
4. Samy Lamouille
5. O. De Wever

In Molecular Biology

1. B. Hinz
2. O. De Wever
3. M. Mareel
4. Samy Lamouille
5. R. Derynck
6. Yoko Katsuno
7. J. Massagué
8. Y. Fouad

In Oncology

1. B. Hinz
2. M. Mareel
3. O. De Wever
4. R. Derynck
5. Samy Lamouille
6. Yoko Katsuno
7. Y. Fouad
8. C. Aanei

Citations in the corpus

• In search of definitions: Cancer‐associated fibroblasts and their markers (2019, background): “Fibroblasts greatly influence the tumor environment via the secretion of cytokines and chemokines, such as vascular endothelial growth factor A (VEGFA)(7) and C-X-C Motif Chemokine Ligand 12 (CXCL12).(8) It has been hypothesized that cross-talk between tumorigenic cells and fibroblasts (Fig.”
• Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy (2019, background): “Fundamentally, many other CAF-derived factors, such as matrix metallopeptidase 2 (MMP2), CXCL12, TGF-β, and IL-6, can promote the proliferation and invasion of cancer cells in various tumors [16].”
• Stroma Cells in Tumor Microenvironment and Breast Cancer (2012, neutral): “SDF-1 stroma-derived factor, TNF-α tumor necrosis factor, TGF-β transforming growth factor-β, NF-κB nuclear factor κB, MMP-7,9,11 matrixmetalloproteinase-7, 9, 11, α-SMA alpha smooth muscle actin, FAP fibroblast activation protein, FSP-1 fibroblast-specific protein, PDGFR-α/β platelet-derived growth”
• Tumor-associated stromal cells as key contributors to the tumor microenvironment (2016, background): “In fact, recent data have indicated that tumor-associated stroma are a prerequisite for tumor cell invasion and metastasis and arise from at least six distinct cellular origins: fibroblasts [5], pericytes [6], bone marrow MSCs [6], adipocytes [4], macrophages [7], and immune cells [8] (Fig.”
• Cancer-Associated Fibroblasts: Their Characteristics and Their Roles in Tumor Growth (2015, background): “demonstrated that resident human mammary fibroblasts can convert to CAFs during the course of tumor progression using a co-implantation tumor xenograft model [31].”
• TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013, background): “Autocrine TGF-b and SDF-1 signaling maintain the differentiation of human mammary fibroblasts into myofibroblasts during tumor progression [74].”
• Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “Another essential chemokine, SDF-1 (also termed CXCL12), is also involved in the activation and immune suppression of CAFs.”
• Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. (2012, background): “In the primary tumor microenvironment, resident human mammary and prostate fibroblasts exhibit autocrine signaling loops mediated by TGF 1 and chemokines and differentiated into myofibroblasts.(150) Epigenetic regulation by miRNAs and oxidative stress caused by reactive oxygen species in the primary”