Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates.

By C. Berger, M. Jensen, Peter M. Lansdorp, M. Gough, Carole Elliott, S. Riddell. Journal of Clinical Investigation, 2008

878 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/5b0dcabbc3adc5403ebcf09fd066c853b7782779

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Citations in the corpus

Chimeric antigen receptor-modified T cells derived from defined CD8+ and CD4+ subsets confer superior antitumor reactivity in vivo (2015, positive): “The superior efficacy of CD8 + CAR-T-cells derived from T CM was associated with greater proliferation in vivo (Fig.4E), consistent with our previous observations and other pre-clinical models 38,39 .”
Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. (2014, background): “For instance, in nonhuman primates, only virus-specific cytotoxic T lymphocytes selectively expanded from CD62L(1) cells as a surrogate marker of central-memory T cells, show robust and long-term persistence comparedwith T cells with identical antigen specificity but generated from the CD62L fractio”
Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma (2008, background): “2b ), showing the expected mixture of naive and memory T cell”
Adoptive immunotherapy for cancer: harnessing the T cell response (2012, neutral): “T hücreleri CD62L ekspresyonunu tekrar kazanabilmesine rağmen, farklılaşmanın esas aşamaları sadece tek yönde etkili olarak yürümektedir (124).”
CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients. (2016, positive): “CD8+ TCM cells and their progeny have been shown to have stemness and to exhibit superior persistence compared with TEM cells after adoptive transfer, suggesting a potential advantage of this subset for providing long-term persistence (12, 22).”