Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease

By G. Stokin, C. Lillo, T. Falzone, R. Brusch, E. Rockenstein, Stephanie L Mount, R. Raman, P. Davies, E. Masliah, David S. Williams and 1 more. Science, 2005

1,227 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/9ea91638a7dd809e81162aed8bc5533db810ceb5

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In Cell Biology

1. Ralph A. Nixon
2. A. Cuervo

In Molecular Biology

1. L. Ittner
2. John Q. Trojanowski
3. J. Götz
4. M. Beal
5. F. Platt
6. V. Lee
7. Ralph A. Nixon
8. B. Boland

In Physiology

1. L. Ittner
2. J. Götz
3. Ralph A. Nixon
4. V. Lee
5. John Q. Trojanowski
6. M. Beal
7. E. Mandelkow
8. D. Holtzman

Citations in the corpus

• Mitochondria take center stage in aging and neurodegeneration (2005, background): “In AD, axonal swellings occur early and they are accompanied by proximal collections of mitochondria, which could contribute to loss of distal synapses.(22) Dendritic mitochondria play a critical role in the number and plasticity of spines and synapses.”
• Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease (2008, background): “Axonal swellings developing early in AD brain and in mouse models of AD (Stokin et al., 2005) have been attributed to axonal transport failure.”
• The Basal Forebrain Cholinergic Projection System in Mice Neuron Types in the Basal Forebrain - Chapter 28 The Mouse Nervous System (2012, background): “Reduction of KLC1 in APP transgenic mice (Stokin et al., 2005) increased cholinergic axonal swelling in the nucleus basalis and increased amyloid-b peptide levels and amyloid deposition in cortical areas, implicating axonal transport deficits in the pathogenesis of AD.”
• Mitochondrial Fusion Protects against Neurodegeneration in the Cerebellum (2007, neutral): “In Alzheimer’s disease, similar blockage of neuritic branch points by b-amyloid deposits has been suggested as a mechanism for neurodegeneration (Stokin et al., 2005).”
• Tau-mediated neurodegeneration in Alzheimer's disease and related disorders (2007, background): “Another significant observation was that, in a mouse model of AD-like Aβ pathology, axonal defects that consisted of swellings that contained accumulated abnormal amounts of tau, other proteins and vesicles were found to precede the appearance of Aβ deposits, including SPs, by more than 1 yea”
• Animal models of Alzheimer's disease and frontotemporal dementia (2008, background): “Disrupted axonal transport has been implicated in the pathology of AD and axonal transport defects have been observed in tau and APP transgenic mic”
• Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF (2006, background): “Because early defects in axonal transport have also been associated with Alzheime”