The Sir2 family of protein deacetylases.

By G. Blander, L. Guarente. Annual Review of Biochemistry, 2004

1,586 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/9d4cc1bb0b31a2b0bc0d97db8294a1072f731738

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. L. Guarente
2. M. Haigis
3. D. Sinclair
4. V. Longo
5. E. Seto
6. Brian K. Kennedy
7. Johan Auwerx
8. M. Circu

In Geriatrics and Gerontology

1. Johan Auwerx
2. D. Sinclair
3. L. Guarente
4. M. Haigis
5. E. Verdin
6. C. Cantó
7. E. Seto
8. Joseph A. Baur

In Physiology

1. Johan Auwerx
2. D. Sinclair
3. E. Verdin
4. B. Spiegelman
5. C. Cantó
6. L. Guarente
7. Christoph Handschin
8. M. Haigis

Citations in the corpus

• Molecular mechanisms and potential therapeutical targets in Huntington's disease. (2010, background): “Sirtuins, human histone deacetylases belonging to class III of HDAC enzymes, have been a recent focus of therapeutic development for neurodegenerative diseases (64).”
• NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences (2008, neutral): “, sirtuins) in aging (35); b) poly(ADP-ribose) polymerase-1 (PARP-1)—-a major NAD -consuming en-”
• Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. (2007, background): “These unusual enzymes, which bear virtually no sequence homology to class I and II HDACs (Denu, 2005; Frye, 2000), have emerged as key regulators of cell survival and organismal longevity (Guarente and Picard, 2005).”
• Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription. (2006, background): “Several physiological SIRT1 substrates have been identified including p53, TAFI68, MyoD, FOXO3, PPAR , NF-kB, and HIV-TAT (Blander and Guarente 2004), but little is known about the biological functions of the other mammalian sirtuins.”
• Timing to perfection: the biology of central and peripheral circadian clocks. (2012, background): “Levels of the enzyme SIRT1, which deacetylates histones and several transcription factors (Blander and Guarente, 2004), fluctuate throughout the day (Asher et al., 2008), and its activity may change as well (Nakahata et al., 2008).”
• Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. (2006, background): “Sir2 silences chromatin, enables DNA repair, and is involved in chromosome fidelity during meiosis (Blander and Guarente 2004).”
• Hepatocyte-specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation (2009, background): “elegans, and Drosophila and are essential for life-span extension provided by calorie restriction (Blander and Guarente, 2004).”
• SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. (2006, background): “Silent information regulator (Sir2) genes promote longevity in yeast, C. elegans, and Drosophila (for review, see Blander and Guarente, 2004).”
• Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. (2009, background): “SIRT3 belongs to class III of HDACs, commonly called sirtuins (SIRTs), which need NAD as a cofactor for their deacetylation reaction (4).”
• Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. (2005, background): “Given that mitochondria is an organelle involved in both aging and energy metabolism (Merry, 2004) and that the sirtuin family of proteins function in a NAD dependent manner (Imai et al., 2000; Blander and Guarente, 2004; North and Verdin, 2004), an interesting possibility is that one or more of the”