Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

By E. Michishita, Jean Y. Park, Jenna M. Burneskis, J. C. Barrett, I. Horikawa. Molecular Biology of the Cell, 2005

1,374 citations recorded by the source corpus.

Subfields: Aging, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/df8926a64559754dbd6680d8a16fc8628898af10

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. L. Guarente
2. M. Haigis
3. D. Sinclair
4. Johan Auwerx
5. E. Verdin
6. C. Cantó
7. R. Mostoslavsky
8. F. Alt

In Geriatrics and Gerontology

1. L. Guarente
2. Johan Auwerx
3. D. Sinclair
4. E. Verdin
5. M. Haigis
6. C. Cantó
7. Bor Luen Tang
8. R. Houtkooper

In Physiology

1. D. Sinclair
2. Johan Auwerx
3. E. Verdin
4. C. Cantó
5. Bor Luen Tang
6. L. Guarente
7. M. Haigis
8. R. Houtkooper

Citations in the corpus

• SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways (2013, background): “Cellular Localization of the Lys Succinylation Proteome SIRT5 is thought to localize primarily to mitochondria (Lombard et al., 2007; Michishita et al., 2005; Nakagawa et al., 2009; Schlicker et al., 2008).”
• NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus (2015, background): “The link between metabolism and NAD+ is further solidified by observations that tissue NAD+ levels decrease with high-fat diets (HFDs) (Bai et al., 2011b; Cantó et al., 2012; Kraus et al., 2014; Pirinen et al., 2014; Yang et al., 2014; Yoshino et al., 2011).”
• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. (2006, neutral): “While in vitro deacetylase activity had not been found for SIRT6 (Liszt et al., 2005; Michishita et al., 2005; North et al., 2003), we detected low-level deacetylation of Pol b when incubated with purified SIRT6 (Figure S7A).”
• SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle (2009, neutral): “In the case of SIRT5, the relevant biochemical activity and cellular functions have not been clearly determined, and reports on its location in mitochondria have been equivocal (Lombard et al., 2007; Michishita et al., 2005; Nakamura et al., 2008; Schlicker et al., 2008).”
• Sirtuins: critical regulators at the crossroads between cancer and aging (2007, background): “A conserved histidine residue in the catalytic core of the sirtuins is important for their deacetylase and monoADP-ribosyltransferase activities (Frye, 1999).”
• SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. (2006, result): “These data are in agreement with a recent report that overexpressed SIRT4-GFP is localized to the mitochondria of human fibroblasts (Michishita et al., 2005).”
• Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation (2007, background): “In addition to SIRT3, SIRT4 and SIRT5 have been reported to localize to mitochondria (19, 26).”