The P2Y12 receptor regulates microglial activation by extracellular nucleotides

By S. E. Haynes, Gunther Hollopeter, Guang Yang, Dana Kurpius, M. Dailey, Wen-Biao Gan, D. Julius. Nature Neuroscience, 2006

1,427 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/9cd3bbd2d3ed6c418c914a537ed19b1821f6c581

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Citations in the corpus

Debris clearance by microglia: an essential link between degeneration and regeneration (2008, background): “In addition to the high motility of their processes under normal conditions, they polarize and converge their processes at sites of brain injury attracted by extracellular ATP and mediated via microglial purinoreceptors (Davalos et al., 2005; Haynes et al., 2006).”
Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals (2009, background): “Possible candidate attractant signals which could be released from synapses include glutamate, ATP, brain-derived growth factor, and chemokines (Lessmann et al., 2003; Haynes et al., 2006), in addition to a role of any electrical signals.”
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease. (2017, neutral): “Individual female animals are shown in Figure S1D.”
Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. (2012, neutral): “…imaging studies of fluorescently labeled microglia following a laser-induced injury demonstrated rapid proliferation and movement of ramified microglial cells to the site of injury in response to extracellular ATP released by the injured tissue (Davalos et al., 2005; Haynes et al., 2006).”
Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia (2013, neutral): “Adult Lewis rats were vaccinated (ip) five times (two weeks apart) with a synthetic peptide corresponding to the mouse P2Y12 C terminus (NH2-Cys-Gly-Thr-Asn-Lys-Lys-Lys-Gly-Gln-Glu-Gly-Gly-Glu-Pro-Ser-Glu-Glu-Thr-Pro-Met-OH; Anaspec) 21 .”
The semantics of microglia activation: neuroinflammation, homeostasis, and stress (2021, background): “Different labs have consistently shown that stimulation of NMDA receptors on highly active neurons causes them to release ATP/ADP into the extracellular space, which is detected by microglial P2Y12 receptors [19, 105, 112–114].”
Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission (2011, methodology): “Here, we activated microglia with LPS, a proinflammatory molecule (25, 26), and monitored neuronal activity.”
The Role of Microglia in the Healthy Brain (2011, background): “P2Y12 receptors and chloride channels have been ruled out (Haynes et al., 2006; Hines et al., 2009).”
Microglial physiology: unique stimuli, specialized responses. (2009, background): “The P2Y12 receptor regulates microglial activation by extracellular nucleotides.”
The myeloid cells of the central nervous system parenchyma (2010, background): “The purinoceptor that underlies this response is P2Y 12 (ref”
iPSC-derived human microglia-like cells to study neurological diseases (2017, positive): “P2ry12 and human-specific Tmem119 antibodies were used to assess the homeostatic state and identity of transplanted microglia (Butovsky et al., 2014, Bennett et al., 2016, Haynes et al., 2006).”
Purinergic signalling and disorders of the central nervous system (2008, background): “Following brain trauma, activated P2Y 12 and probably P2X 4 receptor”