The Role of Microglia in the Healthy Brain

By Marie-Eve Tremblay, Beth Stevens, Amanda Sierra, H. Wake, A. Bessis, A. Nimmerjahn. Journal of Neuroscience, 2011

983 citations recorded by the source corpus.

Microglia were recently shown to play unexpected roles in normal brain development and adult physiology. This has begun to dramatically change our view of these resident “immune” cells. Here, we briefly review topics covered in our 2011 Society for Neuroscience minisymposium “The Role of Microglia in the Healthy Brain.” This summary is not meant to be a comprehensive review of microglia physiology, but rather to share new results and stimulate further research into the cellular and molecular mechanisms by which microglia influence postnatal development, adult neuronal plasticity, and circuit function.

Subfields: Developmental Neuroscience, Immunology, Neurology

View Paper: https://www.semanticscholar.org/paper/6afe11f28c9d7094972f44807acfe22731f48aa5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

In Immunology

In Neurology

Citations in the corpus

Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro (2013, background): “In addition to important roles in inflammation, microglia are also critical in developmental processes such as synaptogenesis, and are imperative for the maintenance of neural homeostasis (see, Tremblay et al., 2011; Ekdahl, 2012).”
Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “…a critical role in brain development, activity-dependent synaptic plasticity, and learning in the adult CNS, via activities in regulating cell death, synapse elimination, neurogenesis and neuronal surveillance (for review see Katsumoto et al., 2014; Salter and Beggs, 2014; Tremblay et al., 2011).”
The biphasic function of microglia in ischemic stroke (2017, neutral): “They are able to sense the changes of brain environment and play an important role in various pathological conditions including ischemic stroke (Hanisch and Kettenmann, 2007; Ransohoff and Brown, 2012; Seifert et al., 2006; Tremblay et al., 2011).”
Depression as a microglial disease. (2015, background): “Microglia, which comprise about 10% of all brain cells, play crucial roles in normal development and in the regulation of ongoing structural and functional processes, from individual synapses to neural circuits and behavior [3,8].”
New tools for studying microglia in the mouse and human CNS (2016, result): “Given the attributed functions of these enriched genes, and published hypotheses that young microglia, which are highly phagocytic and less ramified, might be activated (36), we compared our young microglia with LPS-treated microglia.”
Neuroinflammation after traumatic brain injury: opportunities for therapeutic intervention. (2012, neutral): “Therefore, under non-pathological conditions there is continuing low-level microglial activity in the CNS which is primarily involved in activity-dependent synaptic pruning and in repair processes (Tremblay et al., 2011).”
Macrophages: development and tissue specialization. (2015, background): “Microglia actively engulf synaptic material and perform synaptic pruning during postnatal development (22, 175, 176).”
The semantics of microglia activation: neuroinflammation, homeostasis, and stress (2021, neutral): “The underappreciated role of microglia in physiological conditions contrasts earlier work, which mainly focused on microglial function in pathological contexts such as injury and disease, where neuronal death or degeneration is observed [25, 26].”